Protooncogenes

Question 1

Growth factor (1)

Answer 1

PDGFB (astrocytomas)

Question 2

Growth factor receptors (3)

Answer 2

ERBB2 (Her2/neu - trastuzumab - breast, ovarian, gastric)
RET (MEN2A, MEN2B, Medullary thyroid)
KIT (Gastrointestinal stromal tumor, GIST)

Question 3

Signal tranducers (2)

Answer 3

RAS (many tumors)

ABL (BCR-ABL; t(9;22) Philadelphia chromsome; CML and ALL)

Question 4

Nuclear regulators (3)

Answer 4

C-MYC (Burkitt; t(8;14), EBV)
N-MYC (Neuroblastoma)
L-MYC (Small cell carcinoma of the lung)

Question 5

Cell cycle regulators (2)

Answer 5

CCND1 (cyclin D1 - t(11;14), Mantle cell lymphoma)

CDK4 (melanoma)

Question 6

RET

Answer 6

Growth factor receptor

MEN2A, MEN2B, Medullary thryoid

Question 7

PDGFB

Answer 7

Growth factor

Astrocytoma

Question 8

N-MYC

Answer 8

Nuclear regulator

Neuroblastoma

Question 9

ABL

Answer 9

Signal transducer

CML and ALL

Question 10

RAS

Answer 10

Signal transducer

GTPase, many tumors

Question 11

C-MYC

Answer 11

Nuclear regulator

Burkitt Lymphoma

Question 12

CCND1/cyclin D1

Answer 12

Cell cycle regulator

Mantle cell lymphoma

Question 13

ERBB2

Answer 13

Growth factor receptor

HER2/neu - breast, ovarian, gastric

Question 14

L-MYC

Answer 14

Nuclear regulator

Lung cancer

Question 15

KIT (c-kit)

Answer 15

Growth factor receptor

Gastrointestinal stromal tumor (GIST)