Carcinogens Flashcards
Aflatoxin
Hepatocellular carcinoma
Derived from aspergillus molds
Alkylating agents
Leukemia/lymphoma
chemotherapeutic agents
Alcohol
Squamous cell carcinoma (oropharynx, upper esophagus)
Pancreatic cancer
Hepatocellular carcinoma
Arsenic (derived from cigarette smoke)
Squamous cell carcinoma of skin
Squamous cell carcinoma of lungs
Angiosarcoma of liver
Asbestos
Bronchogenic carcinoma > Mesothelioma
Cigarette smoke
Carcinoma of oropharynx, esophagus, lung, kidney, bladder
What component of cigarette smoke is particularly carcinogenic?
Polycyclic hydrocarbons
Nitrosamines
Stomach cancer
Smoked foods; high rate of stomach cancer in Japan
Naphthylamine (derived from cigarette smoke)
Urothelial carcinoma of the bladder
bonus: renal pelvis is also a site of urothelial carcinoma
Vinyl chloride
Angiosarcoma of the liver
Used to make PVC pipe
Nickel
Lung carcinoma
Chromium
Lung carcinoma
Beryllium
Lung carcinoma
Silica
Lung carcinoma
Ionizing radiation
Papillary thyroid carcinoma (orphan annie eye)
AML
CML
Carbon tetrachloride
Liver carcinoma
EBV
Nasopharyngeal carcinoma
Burkitt Lymphoma
CNS lymphoma in AIDS
HHV-8
Kaposi Sarcoma (AIDS)
HBV and HCV
Hepatocellular carcinoma
HTLV-1
Adult T cell leukemia/lymphoma
HPV 16, 18, 31, 33
SCC of the vulva, vagina, anus, and cervix
Adenocarcinoma of the cervix
(Bonus: E6 inhibits p53; E7 inhibits Rb)
Non-ionizing radiation
(non-ionizing = UBV from sunlight)
BCC, SCC, melanoma
(Bonus: forms pyrimidine dimers; xeroderma pigmentosum = defective nucleotide excision repair of pyrimidine dimers)