Proton Pump Inhibitors

Question 1

Name the proton pump inhibitors commonly used in H.pylori eradication

Answer 1

Esomeprazole, omeprazole, pantoprazole

Question 2

Pantoprazole indication

Answer 2

H.pylori eradication regime
GORD/PUD

Question 3

Pantoprazole precautions

Answer 3

Can mask infections, high dose hepatic accumulation

Question 4

Pantoprazole adverse effects

Answer 4

Common = headache, nausea, vomiting, constipation, flatulence

Rare = gynaecomastia, myalgia, acute interstitial nephritis, hypersensitivity reactions, jaundice

Question 5

Omeprazole indications

Answer 5

PUD, GORD, H.pylori eradication
Upper GI effects of NSAIDs

Question 6

Omeprazole contraindications

Answer 6

Omeprazole or esomeprazole allergy

Question 7

Omeprazole precautions

Answer 7

Can hide gastric carcinoma
Electrolyte disturbances risk

Question 8

Omeprazole adverse effects

Answer 8

Common = headache, vomiting, nausea, constipation, flatulence

Rare = gynaecomastia, myalgia, acute interstitial nephritis, jaundice, hypersensitivity reaction, hypomagnesaemia, hypocalcaemia, hypokalaemia

Question 9

Omeprazole monitoring

Answer 9

Enteric infection