Proto-oncogenes

Question 1

ABL

Answer 1

Tyrosine Kinase
Translocation (9;22) - CML
“Philadelphia chromosome”
Point mutation - ALL

Question 2

RET

Answer 2

Neurotrophic receptors
Point
MEN 2A/B
fam med thyroid carcinoma

Question 3

BRAF

Answer 3

Raf transduction
Papillary Thyroid
Melanoma

Question 4

C-KIT

Answer 4

KIT ligand receptor
Point
GI stromal tumors
Seminomas

Question 5

KRAS

Answer 5

GTP BP
Point
Pancreas, colon, lung

Question 6

C-MYC

Answer 6

Transcription activator
Translocation (8;14)
Burkitt Lymphoma

Question 7

L-MYC

Answer 7

Transcriptional activator
Amplification
Lung carcinoma (small cell)

Question 8

CCND1

Answer 8

Cyclin
Translocation (11;14)
Mantle Cell lymphoma

Question 9

ERBB1/2 (HER)

Answer 9

Estrogen GFR family
Mutation amplification
Adenocarcinoma of lung
Breast carcinoma

Question 10

N-MYC

Answer 10

Transcription activator
Amplification
Neuroblastoma

Question 11

PML/RAR

Answer 11

Retinoic acid mutation (t15;17) causes maturation arrest of pro-myelocytes
Acute pro-myelocytic leukemia (AML-M3)

Question 12

FLI1/EWSRA1

Answer 12

t(11;22)
Ewing sarcoma
16 y/o boy
“onion skin”