Proteinuria Flashcards
Normal subjects excrete ___ protein
(< 150 mg/24 hours)
Most of the protein is reabsorbed in the __ via ____
PT, endocytosis.
the Most abundant protein seen in the normal amount of proteins excreted in the urin
Tamm-Horsfall protein
THP aka ___: is a glycoprotein produced by the medullary ____
uromodulin, thick ascending limb
Tamm-Horsfall protein function
defense against UTI and stones
Matrix for urinary casts
How does dipstick measure protein?
By measuring pH
Dipstick is very sensitive to
criticism, amz7 ALBUMIN
_ of dipstick?
cannot detect low proteinuria between 150-500,
low sens exempt to albumin
if u have a significant proteinuria on the 24 hrs urine collection but on dipstick there is no much proteins, u should think of _____
Myleoma
Gold standard for protein quantification
24-hour urine collection for protein
Most accurate test to monitor treatment
24-hour urine collection for protein
Which test rules out pathologic proteinuria?
Random urine protein to Cr ratio
What to do if u have + result on 24 urine collection?
confirm with Random urine protein to Cr ratio
Neutrophil Gelatinase Associated Lipocalin is for
AKI
Bence Jones proteinuria is for
Light chain
LMW proteinuria is associated with ___ disease:
Tubulointerstitial disease
Tubular protein example:
a1-macroglobulin
B2 mAcroglobulin
Transient proteinuria is usually ___
mild
Transient proteinuria is associated with
CHD. INFECTION, stress related illness
If the patient has high BP, hematuria, low GFR, non-nephrotic proteinuria. WHAT DO WE DO?
Biopsy
What decreases AER?
NSAIDS, ACEI
What increases AER?
HF, Exercise, UTI, hematuria, period pregnancy.
Urine albumin:Cr Ratio is increased in
diabetic nephropathy
The severity of proteinuria correlates with
Kidney disease prognosis
If the patient doesn’t have transient, postural, functional and low grade proteinuria. what we do?
BIOPSY
NEPHROTIC SYNDROME protein level
excretion > 3.5 g/24 h
