Proteinuria Flashcards

1
Q

Normal subjects excrete ___ protein

A

(< 150 mg/24 hours)

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2
Q

Most of the protein is reabsorbed in the __ via ____

A

PT, endocytosis.

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3
Q

the Most abundant protein seen in the normal amount of proteins excreted in the urin

A

Tamm-Horsfall protein

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4
Q

THP aka ___: is a glycoprotein produced by the medullary ____

A

uromodulin, thick ascending limb

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5
Q

Tamm-Horsfall protein function

A

defense against UTI and stones

Matrix for urinary casts

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6
Q

How does dipstick measure protein?

A

By measuring pH

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7
Q

Dipstick is very sensitive to

A

criticism, amz7 ALBUMIN

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8
Q

_ of dipstick?

A

cannot detect low proteinuria between 150-500,

low sens exempt to albumin

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9
Q

if u have a significant proteinuria on the 24 hrs urine collection but on dipstick there is no much proteins, u should think of _____

A

Myleoma

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10
Q

Gold standard for protein quantification

A

24-hour urine collection for protein

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11
Q

Most accurate test to monitor treatment

A

24-hour urine collection for protein

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12
Q

Which test rules out pathologic proteinuria?

A

Random urine protein to Cr ratio

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13
Q

What to do if u have + result on 24 urine collection?

A

confirm with Random urine protein to Cr ratio

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14
Q

Neutrophil Gelatinase Associated Lipocalin is for

A

AKI

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15
Q

Bence Jones proteinuria is for

A

Light chain

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16
Q

LMW proteinuria is associated with ___ disease:

A

Tubulointerstitial disease

17
Q

Tubular protein example:

A

a1-macroglobulin

B2 mAcroglobulin

18
Q

Transient proteinuria is usually ___

A

mild

19
Q

Transient proteinuria is associated with

A

CHD. INFECTION, stress related illness

20
Q

If the patient has high BP, hematuria, low GFR, non-nephrotic proteinuria. WHAT DO WE DO?

A

Biopsy

21
Q

What decreases AER?

A

NSAIDS, ACEI

22
Q

What increases AER?

A

HF, Exercise, UTI, hematuria, period pregnancy.

23
Q

Urine albumin:Cr Ratio is increased in

A

diabetic nephropathy

24
Q

The severity of proteinuria correlates with

A

Kidney disease prognosis

25
Q

If the patient doesn’t have transient, postural, functional and low grade proteinuria. what we do?

A

BIOPSY

26
Q

NEPHROTIC SYNDROME protein level

A

excretion > 3.5 g/24 h