Hematuria and Cancer Flashcards
We need to have more than ____ RBC to consider it Hematuria
3/hpf
How to screen for hematuria?
Dipstick
How sensitive is dipstick screening?
95%
How specific is dipstick screening?
80%
How to confirm hematuria?
microscopy of > 3 RBC
Pink/Cola urine indicates:
Gross Hematuria
Which type of Hematuria is associated with more life threatening conditions?
Gross Hematuria (5 times more)
Initial hematuria
The first few drops are bloody
from urethra
Terminal hematuria
The last few drops are bloody
from bladder neck/prostatic urethra
Total hematuria is from
bladder or upper tract
Most common type of hematuria?
Total hematuria
Initial/terminal hematuria are secondary to
inflammation
If the urine has wormlike clots , the bleeding is from
upper track
Visible, painless, intermittent hematuria might be:
CANCER
Lady with non-visible hematuria and dysuria
most likely infection
Elevated levels of BUN and creatinine suggest
significant renal disease as the cause of hematuria
Gold Standard Investigations in Hematuria are
CT abdomen with contrast + Cystoscopy
95% of bladder cancer is
TCC
What’s this thing in Egypt that raise the change of getting bladder cancer? which type of cancer?
schistosomiasis, squamous
number 1 risk factor for bladder cancer is
smoking
Pain in the loin or pyelonephritis may indicate
ureteric obstruction and hydronephrosis.
grade of bladder cancer is determined by
how the cancer cells look in comparison with normal bladder cells.
The stage is determined by
he cancer growth in the bladder wall and how far it has spread
T4 bladder cancer is
invasive of pelvic wall or nearby organs
invasion of perivesical fat is which stage?
T3
T1 is invasion of ___ only
lamina propria
multicentic means?
you could get multiple at the same time
Which is more aggressive cancer in situ or Ta tumor?
Cancer in situ. 50% will die
The tumour with muscle invasion is nearly always ___
solid
treatment of non-invasive tumors
Endoscopic surgery (TURBT)(Trans Urethral Resection of Bladder Tumor)
Follow-up cystoscopies are essential after
Endoscopic surgery
Chemotherapy drug that prevents recurrence of the tumor, but can’t prevent progression
MitomycinC
the only treatment for carcinoma in situ.
BCG
Invasive tumour TREATMENT
Radical cystectomy.
Urinary diversion is done with
Radical cystectomy.
Diversion of urine by:
- Ileal conduit.
* Orthotopic ileal neobladder.
the gold standard excision of bladder
Radical cystectomy
initial chemotherapy followed by radiotherapy in what?
in responding tumors (invasive)
______ diversion Is the first option unless tumor involve the proximal/distal urethra
Orthotopic neobladder, proximal
Ileal condouit takes part of the
illium