Proteins- Structure and Function

Question 1

Which type of bonding is responsible for the secondary structure of proteins?

Answer 1

Hydrogen bonding between the C=O and N-H groups of peptide bonds

Question 2

Define the ‘quaternary structure’

Answer 2

The arrangement of two or more polypeptide subunits into a single functional complex.

Question 3

How are the helices stabilised in a collagen protein

Answer 3

Hydroxylated proline residues allow hydrogen bonding.

Question 4

Which amino acid is most likely to disrupt an alpha helix

Answer 4

proline

Question 5

How are secondary structures stabilised in proteins

Answer 5

Through hydrogen bonds joining different parts of the peptide backbone

Question 6

Which amino acid can form disulphide bonds

Answer 6

Cysteine

Question 7

What is a protein domain

Answer 7

A discrete region of polypeptide chain that has folded into a self contained three dimensional structure.

Question 8

What is the effect of glutamic acid to valine substitution upon the quaternary structure of hemoglobin

Answer 8

Hydrophobic interactions between hemoglobin tetramers cause aggregation.