Proteins (c) (iii) Reversible Binding of Phosphate and the Control of Conformation Flashcards
The addition or removal of phosphate can cause…
Reversible conformational changes in proteins.
This is a common form of…
Post-translational modification
Protein Kinase catalyses…
The transfer of a phosphate group to other proteins (dephosphorylated protein—> phosphorylated protein)
The terminal phosphate of ATP is transferred to…
Specific R groups
Protein phosphatase catalyses
The reverse reaction (removes phosphorylase from the previously phosphorylated protein.) (phosphorylated protein——>dephosphorylated protein)
Phosphorylation brings about…
Conformational changes, which can affect a proteins activity
Therefore, the activity of many cellular proteins (eg. enzymes and receptors) are regulated by…
Reversible binding of Phosphates (Reversible phosphorylation)
Some proteins are activated by phosphorylation while others are…
Inhibited
Adding a phosphate group adds…
Negative charges. Therefore, Ionic interactions in the unphosphorylated protein can be disrupted and new ones created.
