Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

UWorld > Proteins/antibodies associated w/ conditions > Flashcards

Proteins/antibodies associated w/ conditions Flashcards

1
Q

Primary biliary cirrhosis

A

Anti-mitochondrial Abs (AMA) (90%)

Anti-nuclear Abs (70%)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Anti-mitochondrial Abs (AMA)

A

Primary biliary cirrhosis (90%)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Anti-nuclear Abs (ANA)

A 
Suspected CVD
SLE (including drug-induced lupus)
Rheumatoid arthritis
Polymyositis or dermatomyositis
Type 1 autoimmune hepatitis
Primary biliary cirrhosis (70%)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

SLE

A

Anti-nuclear Abs (ANA) (very sensitive, 95%)
Anti-ds DNA Abs (very specific, esp nephritis)
Anti-Smith Abs (very specific, only 30-50%)
False positive RPR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Type 1 autoimmune hepatitis

A

Anti smooth muscle antibodies

Anti-nuclear Abs (ANA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Anti-smooth muscle Abs

A

Type 1 autoimmune hepatitis

Acute and chronic hepatitis (esp chronic active)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Anti-LKM Abs

A

Type 2 autoimmune hepatitis

Acute and chronic hepatitis (esp chronic active)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Acute / chronic hepatitis

A

Anti-smooth muscle Abs

Anti-LKM Abs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Anti-Smith Abs

A

SLE (very specific, only 30-50%)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Churg-Strauss syndrome

A

p-ANCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Microscopic polyangiitis

A

p-ANCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Anti-TPO Abs

A

Hashimoto’s thyroiditis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Antithyroglobulin Abs

A

Hashimoto’s thyroiditis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Anti-TSI Abs

A

Graves’ disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Hashimoto’s thyroiditis

A

Anti-TPO Abs

Antithyroglobulin Abs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Graves’ disease

A

Anti-TSI Abs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

BCR-ABL

A

CML

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

CML

A

BCR-ABL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

ADAMTS13

A

TTP (decreased activity)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

TTP

A

Decreased activity of ADAMTS13

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Antiphospholipid antibody syndrome

A

Anti-cardiolipin Abs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Anti-cardiolipin Abs

A

Antiphospholipid antibody syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Anti-ds DNA Abs

A

SLE (esp lupus nephritis; very specific for SLE)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

RF

A

Rheumatoid arthritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Anti-cyclic citrullinated peptide Abs
Rheumatoid arthritis
26
Rheumatoid arthritis
RF Anti-cyclic citrullinated peptide Abs ANA HLA-DR4
27
Celiac disease
Anti-tissue transglutaminase Abs (anti tTg) Anti-endomysial Abs (both IgA so can look normal in selective IgA deficiency)
28
Anti-tissue transglutaminase Abs
Celiac disease
29
Anti-endomysial Abs
Celiac disease
30
Heterophile antibodies
Infectious mononucleosis (may be negative early)
31
Infectious mononucleosis
Heterophile antibodies (may be negative early)
32
p-ANCA
``` Allergic granulomatosis w/ angiitis (Churg-Strauss) Microscopic polyangiitis Ulcerative colitis Pauci-immune RPGN Primary sclerosing cholangitis (maybe) Rarely Crohn's ```
33
Allergic granulomatosis w/ angiitis (Churg-Strauss)
p-ANCA
34
c-ANCA
Granulomatosis w/ polyangiitis (Wegener's)
35
Granulomatosis w/ polyangiitis (Wegener's)
c-ANCA
36
Anti-GBM antibodies
Goodpasture syndrome
37
Goodpasture syndrome
Anti-GBM antibodies
38
Ulcerative colitis
p-ANCA Rarely ASCA HLA-B27
39
Crohn's disease
ASCA Rarely p-ANCA HLA-B27
40
ASCA
Crohn's disease | Rarely ulcerative colitis
41
HLA-B27
``` Seronegative arthropathies (RF neg) PAIR Psoriatic arthritis Ankylosing spondylitis IBD (Crohns/UC) Reactive arthritis (Reiter's) ```
42
Psoriatic arthritis
HLA-B27
43
Ankylosing spondylitis
HLA-B27 (90%)
44
Reactive arthritis (Reiter's)
HLA-B27
45
Primary sclerosing cholangitis
p-ANCA (maybe) | Negative ANA, AMA
46
Type 2 autoimmune hepatitis
Anti-LKM antibodies | Anti liver cytosol antibodies
47
Anti liver cytosol antibodies
Type 2 autoimmune hepatitis
48
Pauci-immune RPGN
p-ANCA
49
HLA-DR4
Rheumatoid arthritis
50
Anti-histone antibodies
Drug-induced lupus
51
Drug-induced lupus
ANA | Anti-histone antibodies
52
Polymyositis or dermatomyositis
ANA | Anti-Jo-1 antibodies
53
Anti-Jo-1 antibodies
Polymyositis or dermatomyositis
54
Scleroderma
Anti-scl-70 ANA | Anti-topoisomerase antibodies
55
Anti-scl-70 ANA
Scleroderma
56
Anti-topoisomerase antibodies
Scleroderma
57
CREST
Anti-centromere antibodies
58
Anti-centromere antibodies
CREST
59
Anti-RNP ANA
Mixed connective tissue disorder
60
Mixed connective tissue disorder
Anti-RNP ANA
61
Anti-Ro (anti-SSA) ANA
Sjogren syndrome
62
Anti-La (anti-SSB) ANA
Sjogren syndrome
63
Sjogren syndrome
Anti-Ro (anti-SSA) ANA | Anti-La (anti-SSB) ANA

UWorld (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions