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UWorld > Proteins/antibodies associated w/ conditions > Flashcards

Proteins/antibodies associated w/ conditions Flashcards

1
Q

Primary biliary cirrhosis

A

Anti-mitochondrial Abs (AMA) (90%)

Anti-nuclear Abs (70%)

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2
Q

Anti-mitochondrial Abs (AMA)

A

Primary biliary cirrhosis (90%)

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3
Q

Anti-nuclear Abs (ANA)

A 
Suspected CVD
SLE (including drug-induced lupus)
Rheumatoid arthritis
Polymyositis or dermatomyositis
Type 1 autoimmune hepatitis
Primary biliary cirrhosis (70%)
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4
Q

SLE

A

Anti-nuclear Abs (ANA) (very sensitive, 95%)
Anti-ds DNA Abs (very specific, esp nephritis)
Anti-Smith Abs (very specific, only 30-50%)
False positive RPR

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5
Q

Type 1 autoimmune hepatitis

A

Anti smooth muscle antibodies

Anti-nuclear Abs (ANA)

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6
Q

Anti-smooth muscle Abs

A

Type 1 autoimmune hepatitis

Acute and chronic hepatitis (esp chronic active)

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7
Q

Anti-LKM Abs

A

Type 2 autoimmune hepatitis

Acute and chronic hepatitis (esp chronic active)

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8
Q

Acute / chronic hepatitis

A

Anti-smooth muscle Abs

Anti-LKM Abs

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9
Q

Anti-Smith Abs

A

SLE (very specific, only 30-50%)

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10
Q

Churg-Strauss syndrome

A

p-ANCA

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11
Q

Microscopic polyangiitis

A

p-ANCA

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12
Q

Anti-TPO Abs

A

Hashimoto’s thyroiditis

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13
Q

Antithyroglobulin Abs

A

Hashimoto’s thyroiditis

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14
Q

Anti-TSI Abs

A

Graves’ disease

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15
Q

Hashimoto’s thyroiditis

A

Anti-TPO Abs

Antithyroglobulin Abs

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16
Q

Graves’ disease

A

Anti-TSI Abs

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17
Q

BCR-ABL

A

CML

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18
Q

CML

A

BCR-ABL

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19
Q

ADAMTS13

A

TTP (decreased activity)

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20
Q

TTP

A

Decreased activity of ADAMTS13

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21
Q

Antiphospholipid antibody syndrome

A

Anti-cardiolipin Abs

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22
Q

Anti-cardiolipin Abs

A

Antiphospholipid antibody syndrome

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23
Q

Anti-ds DNA Abs

A

SLE (esp lupus nephritis; very specific for SLE)

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24
Q

RF

A

Rheumatoid arthritis

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25
Q

Anti-cyclic citrullinated peptide Abs

A

Rheumatoid arthritis

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26
Q

Rheumatoid arthritis

A

RF
Anti-cyclic citrullinated peptide Abs
ANA
HLA-DR4

27
Q

Celiac disease

A

Anti-tissue transglutaminase Abs (anti tTg)
Anti-endomysial Abs
(both IgA so can look normal in selective IgA deficiency)

28
Q

Anti-tissue transglutaminase Abs

A

Celiac disease

29
Q

Anti-endomysial Abs

A

Celiac disease

30
Q

Heterophile antibodies

A

Infectious mononucleosis (may be negative early)

31
Q

Infectious mononucleosis

A

Heterophile antibodies (may be negative early)

32
Q

p-ANCA

A 
Allergic granulomatosis w/ angiitis (Churg-Strauss)
Microscopic polyangiitis
Ulcerative colitis
Pauci-immune RPGN
Primary sclerosing cholangitis (maybe)
Rarely Crohn's
33
Q

Allergic granulomatosis w/ angiitis (Churg-Strauss)

A

p-ANCA

34
Q

c-ANCA

A

Granulomatosis w/ polyangiitis (Wegener’s)

35
Q

Granulomatosis w/ polyangiitis (Wegener’s)

A

c-ANCA

36
Q

Anti-GBM antibodies

A

Goodpasture syndrome

37
Q

Goodpasture syndrome

A

Anti-GBM antibodies

38
Q

Ulcerative colitis

A

p-ANCA
Rarely ASCA
HLA-B27

39
Q

Crohn’s disease

A

ASCA
Rarely p-ANCA
HLA-B27

40
Q

ASCA

A

Crohn’s disease

Rarely ulcerative colitis

41
Q

HLA-B27

A 
Seronegative arthropathies (RF neg)
PAIR
Psoriatic arthritis
Ankylosing spondylitis
IBD (Crohns/UC)
Reactive arthritis (Reiter's)
42
Q

Psoriatic arthritis

A

HLA-B27

43
Q

Ankylosing spondylitis

A

HLA-B27 (90%)

44
Q

Reactive arthritis (Reiter’s)

A

HLA-B27

45
Q

Primary sclerosing cholangitis

A

p-ANCA (maybe)

Negative ANA, AMA

46
Q

Type 2 autoimmune hepatitis

A

Anti-LKM antibodies

Anti liver cytosol antibodies

47
Q

Anti liver cytosol antibodies

A

Type 2 autoimmune hepatitis

48
Q

Pauci-immune RPGN

A

p-ANCA

49
Q

HLA-DR4

A

Rheumatoid arthritis

50
Q

Anti-histone antibodies

A

Drug-induced lupus

51
Q

Drug-induced lupus

A

ANA

Anti-histone antibodies

52
Q

Polymyositis or dermatomyositis

A

ANA

Anti-Jo-1 antibodies

53
Q

Anti-Jo-1 antibodies

A

Polymyositis or dermatomyositis

54
Q

Scleroderma

A

Anti-scl-70 ANA

Anti-topoisomerase antibodies

55
Q

Anti-scl-70 ANA

A

Scleroderma

56
Q

Anti-topoisomerase antibodies

A

Scleroderma

57
Q

CREST

A

Anti-centromere antibodies

58
Q

Anti-centromere antibodies

A

CREST

59
Q

Anti-RNP ANA

A

Mixed connective tissue disorder

60
Q

Mixed connective tissue disorder

A

Anti-RNP ANA

61
Q

Anti-Ro (anti-SSA) ANA

A

Sjogren syndrome

62
Q

Anti-La (anti-SSB) ANA

A

Sjogren syndrome

63
Q

Sjogren syndrome

A

Anti-Ro (anti-SSA) ANA

Anti-La (anti-SSB) ANA

UWorld (2 decks)

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