Proteins Flashcards
1
Q
How do Adenoviruses speed up translation start?
A
5’ UTR hairpins shunt ribosome to start codon
2
Q
How do viruses increase translation rate?
A
Single genomic transcripts which are processed afterwards
3
Q
How is translation normally initiated?
A
eIF4F is recruited to mRNA cap and recruits 43S initiation ribosome
Scans to start codon
Recruits 60S ribosome
Closed loops model
4
Q
What is the mRNA cap?
A
M7 guanosine
G-ppp-mRNA
5
Q
Which kinases inhibit eIF2 regeneration?
A
GCN1 in amino starvation
HR1 in haem starvation
PERK in ER stress
PRK in dsDNA binding
