Evading Apoptosis

Question 1

How can the viral evasion of apoptosis be broadly classified?

Answer 1

Protease inhibitors
Stimulate anti death pathways
Regulation of TFs

Question 2

Why do viruses evade apoptosis?

Answer 2

Live cells are needed for replication

For latency

Question 3

How is extrinsic apoptosis activated?

Answer 3

Ligands activate death domain proteins
DD activate caspase 8 pro removal
Caspase 8 activates C3 executioner

Question 4

What are caspases?

Answer 4

Cys catalysed asp targeting proteases related to interleukin converting enzyme

Question 5

How can external apoptosis be inhibited?

Answer 5

Receptor internalisation
Caspases inhibitors
Caspase cleavage

Question 6

How are caspases cleaved?

Answer 6

CrmA serpin encoded by cowpox

Question 7

Which virus inhibits extrinsic apoptosis using receptor internalisation?

Answer 7

Adenovirus E3 : RID complex

Question 8

Which viruses inhibit caspases?

Answer 8

KSHV and pox viruses encode vFLIPs

Question 9

How does a vFLIP inhibit apoptosis?

Answer 9

Uses homology to death domains to inhibit caspase 8