Proteins Flashcards
CHON is called amphoteric because
Has positive and negative charges
CHON provide ______ of the total daily body energy requirement
12-20%
CHON are _______ of the cell’s dry weight
50-70%
Proteins come from greek word
“proteis”- first rank of importance
Actual 3-dimensional configuration of protein
Tertiary structure
Winding of the polypeptide chain: what structure?
Secondary structure
Glucogenic amino acids generate what precursors of glucose?
Pyruvate and citric avid cycle intermediates
Linear sequence of the amino acid
Primary structure
Balance between anabolism and catabolism
Nitrogen balance
Anabolism > catabolism
Positive Nitrogen Balance
Catabolism > anabolism
Negative Nitrogen Balance
Percent of nitrogen content in serum CHON
16%
CHON = _____ x N
6.25
Other name of prealbumin
Transthyretin
RV of prealbumin
18-45mg/dl
General transport CHON
Albumin
Folding pattern of protein
Tertiary structure
Serves a circulating reservoir of AA
Albumin
CHON that binds quinidine
a1- acid glycoprotein
Other name for alpha1- acid glycoprotein
Orosomucoid
Neutralizes neutrophil elastase that destroy lung alveoli
Alpha1-antitrypsin
Major inhibitor of protease activity
Alpha-1 antitrypsin
Transport T4T3 and retinol
Prealbumin
Maintains osmotic/oncotic pressure
Albumin
CHON is synthesized in
Liver
Lowest level of Albumin is seen in
Nephrotic syndrome
Maternal serum AFP is done between
15 and 20 weeks of gestation
As landmark to confirm that the specimen is CSF
Prealbumin
Useful diagnostic tool in neonates with bacterial infections
Alpha-1 acid glycoprotein
Half life of prealbumin
2 days
Major form of PSA found in human sera
Alpha-1 antichymotrypsin
CHON that is associated with Alzheimer’s disease
Alpha-1 antichymotrypsin
Indicator of nutrition
Albumin
Sensitive and highly prognostic marker of cystic fibrosis
Albumin
Prealbumin is rich in
Tryptophan and 0.5% CHO
Binds heme
Hemopexin
Ceruloplasmin imparts what color in protein?
Blue
Increase level of AFP is used to assess ______ of fetus
Neural tube effects
For diagnosis of early hemolysis
Hemopexin
Level of ceruloplasmin in Wilson’s diease
0.1 g/L
Copper deposition in cornea of Wilson’s disease is what you called?
Kayser-Fleisher rings
Reference value for Ceruloplasmin
18-45mg/dL
B2- microglobulin is needed in production of what cells
CD8 cells
CHON with affinity to vitamin D and actin
Group-specific component globulin
Alpha-1 antichymotrypsin is a serine proteinase with
Cathepsin G
Other name of transferrin
Siderophilin
Light chain component of HLA
B2- microglobulin
Alpha-2 macroglobulin inhibits
Trypsin, pepsin and plasmin
Major component of B2- microglobulin
Transferrin
Early warning test for person at risk of coronary artery disease
CRP
Marker for long term prognosis of cardiovascular disease
Fibrinogen
Most abundant complement in serum
C3
CHON that is important in pathogenesis of age-related macular degeneration
C3
Has greatest affinity to progesterone
Alpha-1 acid glycoprotein
Gold standard in acute coronary syndrome
Troponin
General scavenger molecule
CRP
In extensive coagulation, fibrinogen is
Decrease
CHON helps in evaluation of Intravascular hemolysis
Haptoglobin
Ketogenic Amino acids are degraded to
Acetyl CoA