Proteins Flashcards
What are the different structures of Protein
Primary, Secondary, Teritary Quaternary
What compounds are proteins made of?
Carbon, Nitrogen, Oxygen , Hydrogen
What is usually written on the left hand side of a primary protein?
N- Termina (Amino Terminal)
What is the angle of rotation in a Primary protein called?
Ramachandran Angle
What is an example of a Primary protein?
Insulin
Describe the peptide bond in a primary protein?
Partially DOUBLE BONDED
How many chains make up insulin?
2 Polypeptide chains
What are the polypeptide chains that make up insulin ?
A chain (Glycine)
B chain (Phenyl alanine)
These chains are held by what bonds?
2 Inter chain disulphide bonds
A chain ( 7th cystine ) - B chain (7th cystine)
A chain (20th cystine)- B chain (19th cystine)
A chain (6th cystine ) to A chain (11th cystine)
What disease is caused if there is a change from Glutamic acid to Valine ?
Sickle cell anaemia
What are the bonds that hold together a Secondary Protein?
Hydrogen, Hydrophobic Interactions, Electrostatic Bonds, Van Der Waals forces
Who discovered the Alpha helix structure and when?
Linus PAULING
Robert B. COREY and 1951
Features of a alpha helix sheet
- Most common
- Stable ( hydrogen bonds)
3.Each turn is 3.6 Amino acids
4.Spiral sturcture - Right- handed
What can destabilise the hydrogen binds in a secondary protein?
Proline , Hydroxyproline, Glycine
Where can secondary proteins be found?
Myoglobin and Haemoglobin
