Proteins Flashcards
Collagen
Structural protein: trihelical fiber makes up most of the extrasolar matrix of connective tissue, function: provides strength and flexibility
Elastin
Structural protein: important component of ECM, function: stretch and recoil to restore original shape of tissue
Keratin
Structural protein: intermediate filament protein found in epithelial cells, function: regulatory and mechanical integrity
Actin
Structural protein: makes up micro filaments and thin filaments in myofibrils, polar, function: motor proteins can travel unidirectional along actin filament
Tubulin
Structural protein: makes up microtubules, polar, function: providing structure, chromosome separation, intercellular transport with kinesin and dynein
Myosin
Motor protein: interacts with actin, involved as the thick filaments of a myofibril and cellular transport
Kinesin
Motor protein: involved in aligning chromosome during metaphase and depolymerizing microtubules during anaphase, brings vesicles toward positive end of microtubules
Dynein
Motor protein: involved in sliding movement of cilia and flagella, brings vesicles toward negative end of microtubules
Cell adhesion molecules (CAMs)
Proteins found in the surface of cells, function: binding cell to ECM or other cells. Includes CADHERINS, INTEGRINS, and SELECTINS
Cadherin
Group of glycoproteins that mediate calcium-dependent cell adhesion, often hold similar cell type together
Integrins
Group of proteins that have alpha and beta chains, function: cellular signaling
Selectins
Bind to carbohydrates molecules that project from other cell surfaces (weakest of the CAM bonds), function: host defense including inflammation and white blood cell migration
Antibody (Immunoglobulin)
Proteins produced by B-cells, function: neutralize targets in the body and recruit other cells to help eliminate
Three outcomes: neutralizing, marking for destruction by other WBC, or agglutination
