Protein Synthesis Inhibitors 50s- Macrolides

Question 1

Macrolides

Answer 1

1. erythromycin (Erybid®, Eryc®)
2. clarithromycin (Biaxin®)
3. azithromycin (Zithromax®)

Question 2

erythromycin (Erybid®, Eryc®)

Coverage

Answer 2

• GP except Enterococcus
• GN: Legionella, B. pertussis
• “Atypicals”: Chlamydophila, Mycoplasma

Question 3

erythromycin (Erybid®, Eryc®)

MOA

Answer 3

Binds to 50S ribosomal subunit inhibiting protein synthesis

Question 4

erythromycin (Erybid®, Eryc®)

Adverse Effects

Answer 4

• GI upset
  
  • llimits clinical usage
• Acute cholestatic hepatitis
• Prolonged QT

Question 5

erythromycin (Erybid®, Eryc®)

Indications

Answer 5

• Susceptible RTI
• pertussis
• diphtheria
• Legionnaires’ disease
• skin and soft tissue infections

Question 6

erythromycin (Erybid®, Eryc®)

Contraindications

Answer 6

• Hypersensitivity to erythromycin
• Concurrent therapy with
  
  • astemizole
  • terfenadine

Question 7

clarithromycin (Biaxin®)

Coverage, AE, MOA

Answer 7

same as erythromycin but has effects on some mycobacteria

Question 8

clarithromycin (Biaxin®)

Indications

Answer 8

• Susceptible RTI
• skin infections
• non-tuberculous mycobacterial infections
• part of multidrug therapy for H. pylori treatment

Question 9

clarithromycin (Biaxin®)

contraindications

Answer 9

Hypersensitivity to macrolides

Question 10

azithromycin (Zithromax®)

Coverage, MOA, AE, CI

Answer 10

same as clarithromycin

Question 11

azithromycin (Zithromax®)

Indications

Answer 11

• Susceptible RTI
• acute exacerbations of COPD
• community-acquired pneumonia
• skin infections
• Campylobacter infections if treatment indicated
• chlamydia