Protein Synthesis Inhibitors 30s- Aminoglycosides

Question 1

gentamicin tobramycin amikacin (Amikin®)

Coverage

Answer 1

GN (includes Pseudomonas)

Question 2

gentamicin tobramycin amikacin (Amikin®)

MOA

Answer 2

Binds 30S subunit of ribosome inhibiting protein synthesis

Question 3

gentamicin tobramycin amikacin (Amikin®)

Adverse Effects

Answer 3

• Nephrotoxicity (reversible)
• Vestibular and ototoxicity (irreversible)

NOTE: Vestibular toxicity is the most important aminoglycoside toxicity

Question 4

gentamicin tobramycin amikacin (Amikin®)​

Indications

Answer 4

• GN infections when alternatives do not exist
• UTIs
• used in low doses for synergy with β-lactams or with vancomycin for the treatment of serious infections

Question 5

gentamicin tobramycin amikacin (Amikin®)​

Contraindications

Answer 5

Pre-existing hearing loss and renal dysfunction