Protein Synthesis Inhibitors Flashcards
MOA of Aminoglycosides?
Blocks initiation of translation by blocking Metf tRNA to P site. Induces frameshift mutation.
Cidal
Resistance to aminoglycosides?
Conjugation inactivates (adenylylation, acetylation)
name five aminoglycosides?
Gentamycin Neomycin Amikacin Tobramycin Streptomycin
SE’s of Mean GNATS?
NOT nephrotoxic, neuromuscular blockade ototoxic teratogen dose dependent (hence given only once daily)
On what group of bacteria do aminoglycosides not work?
Anaerobes. oxygen dependent uptake of drug
MOA of tetracyclines?
Blocks binding of aminoacyl tRNA to the A site
MOR to tetracyclines?
activation of efflux pumps
Use of tatracyclines?
Chlamydia, Mycoplasma Ricketsia, Borrelia, Treponema H pylori Brucella Vibrio Acne
Tetracycline with high concentration in prostate and liver metabolism?
Doxycycline
drug stays in saliva tears, dental applications
Monocycline
Why are tetracycline not taken with food?
they chelate Ca and Fe reducing the absorption
Major side effects of tetracyclines?
enamel discoloration, phototoxicity, contraindicated in pregnancy
Tetracycline used to treat SIADH?
demeclocycline blocks ADH receptor
Drug that inhibits translocation of peptidyl tRNA (50s) and is not a macrolide?
Chloramphnicol
Metabolism of Chloramphenicol
P450