Cell Wall Inhibitors Flashcards
class of penicillin G?
Narrow spectrum
Class for Naficillin?
very narrow spec
Class of methicillin?
Very Narrow spec
Class of oxacillin?
Very narrow spec
Use of very narrow spectrum?
Staphylococci (Non MRSA)
Range of narrow spectrum penicillins?
streptococci, meningococci, pneumococci, Trepenoma
Two penicillins excreted in bile?
naficillin, oxacillin
cefazolin
G1 ceph
cephalexin
G1 ceph
Use of G1 cephalosporins?
Gram positive cocci (not MRSA), e coli, klebsiella, porteus (PEcK
Surgical prophylaxis, no CNS activity
Cefotetan
G2 HENS (H flu, enterobacter, Neisseria, S. marcescens)
Cefaclor
G2
Cefuroxime
G2 crosses CNS
Ceftriaxone
G3
Cefotaxime
G3
Cefdinir
G3
Cefixime
G3
Class used for empiric treatment of meningitis and sepsis?
G3 cephalosporins, CNS coverage
class of cephs resistance to betalactamases?
G4
what two cephs are eliminated in bile?
cefoperazone (?) ceftriaxone
What two cephalosporins have disulfiram like effects?
cefoperazone, cefotetan (G3s)
organisms not covered by cephalosporins?
Listeria, Atypicals (mycoplasma, chlamydia), MRSA, enterococci
Empiric use in life-threatening nosocomial infections?
imipenem/meropenem
What drug is given with imipenem to block nephrotoxic metabolite production?
Cilastatin
major SE of imiopenem
50% have seizures
Used for Gram negative rods (pseudomonas) in those with penicllin allergy?
aztreonam
3 side effects of vancomycin
red man syndrome (histamine) ototoxic, nephrotoxic
