Protein Synthesis Inhibitor

Question 1

Aminoglycoside

Answer 1

protein inhibitor, contain cyclohexane ring and amino sugar, bind 30S ribosomal subunit and interfere with protein synthesis by inhibiting process and causing misreading of mRNA; broad range spectrum, G=, mycobacteria; cidal
side effect - deafness, renal damage, nausea, allergies

Question 2

Streptomycin

Answer 2

protein inhibitor: Narrow range, G-, aerobic aminoglycoside

Question 3

Karamycin

Answer 3

protein inhibitor: Broad range, G-, aminoglycoside

Question 4

Neomycin

Answer 4

protein inhibitor: Broad range, G- aminoglycoside

Question 5

Tetracyclones

Answer 5

protein inhibitor: 4 ring, Static; broad spectrum G- and G+; teeth discoloration, hepatic injury, GI upset, combine with 30S ribosomal subunit; inhibit binding of aminoacyl-tRNA to the A site of ribosome

Question 6

Cholratetracycline

Answer 6

protein inhibitor tetracyclone - static, broad spectrum

Question 7

Doxycycline

Answer 7

protein inhibitor tetracyclone - static, broad spectrum

Question 8

Macrolide

Answer 8

protein inhibitor, 12-22 carbon lactone rings linked to one or more sugars; bind to 23S rRNA of 50s ribosomal subunit, inhibit peptide chain elongation, static, can use in penicillin allergy
side effects - hepatic injury, anemia, allergies

Question 9

Erythromycin

Answer 9

protein synthesis inhibitor - macrolide; aerobic and anaerobic G- and G+

Question 10

clindamycin

Answer 10

protein synthesis inhibitor - macrolide;

Question 11

ketolides

Answer 11

protien synthesis inhibition semisynthetic macrolides

Question 12

chloramphenicol

Answer 12

protein synthesis inhibition - binds to 23S rRNA on 50S ribosomal subunit inhibits peptidyl transferase rxn resulting in static action, synthetic broad spectrum, toxic, only used in life threating situations, depressed bone marrow function, allergies

Question 13

Streptogramins

Answer 13

protein synthesis inhibitor: dial, MRSA S aureus and Van Enterococci

Question 14

Quinopristin/Dalfopristin (30/70)

Answer 14

protein synthesis inhibitor, streptogramin. Cidal. Dalfopristin binds 23S rRNA and enhances binding of quinopristin x 100 which inhibits peptide elongation