Nucleic Acid Synthesis Inhibitors

Question 1

Quinolones

Answer 1

broad spectrum, synthetic drugs w 4-quinalone ring, inhibit bacterial DNA gyrase complex, disrupts cell processes involving DNA, side effects = tendonitis headache, convulsion

Question 2

Ciprofloxacin

Answer 2

quinolone, tx for anthrax, inhibits bacterial DNA gyrase complex (nallidixic acid was first quinolone to be synthesized); cidal;

Question 3

levofloxacin

Answer 3

quinolone - broad spectrum cidal