Protein sorting Flashcards
Molecular chaperone
are proteins that facilitate the foldingand translocation of other proteins, but DO NOT provide specific information on what the secondary or tertiary structureof a folded protein should be.
Where does the synthesis of all protein start?
On free Ribosomes.
What are targets of the cytosolic pathway?
Nucleus, mitochondria, chloroplast, perioxsomes,
what are targets of the secretory pathway?
plasma membrane, endosomes, secretory vescicles, lysosomes, ER associated proteins and golgi associated proteins.
What is the entry point for most secretory proteins?
RER
What are the two key steps to vesicular transport?
- get the correct protein into the correct vesicle
2. get the vesicle to it’s correct final destination within the cell
lysosomes
are membrane-enclosed organelles that contain an array of enzymes capable of breaking down all types of biological polymers at acidic pH
Nuclear pore complexes in the nuclear envelope plays an important role in regulating what processes?
gene expression, RNA processing, and ribosome assembly. (for example: RNAs move out; proteins such as transcription factors move in through these complexes)
What can pass freely through the nuclear envelope?
small hydrophobic molecules.
What is an example of a nuclear localization signal ?
transcription factors
