Protein Folding Flashcards
0
Q
why don’t electrostatic interactions each contribute 5kcal/mol to the free energy of folding?
A
the charges are fully solvated by water in the unfolded state (so only 1 from entropy).
1
Q
why don’t H bonds contribute 3 kcal/mol of free energy to folding?
A
because they can also form weak H bonds with water in the UNFOLDED STATE. (so only 1).
