Prostate Cancer

Question 0

What’s the PCA3 test?

Answer 0

Urine test after prostate massage
Looks for DD3 a prostate specific gene.
Helps decide about repeat bx

Question 1

Abnormal PSA velocity

Answer 1

> 0.8 ng/ml/yr

Question 2

Name location of cancer per prostate zone

Answer 2

Peripheral 70%
Transitional 20%
Central 10%

Question 3

What is NCCN (2010) very low risk prostate cancer group

Answer 3

T1c

Gleason<0.15 ng/ml/g

Question 4

Survival benefit of Provenge over placebo?

Answer 4

4.1 months

Question 5

Survival benefit of docetaxel over mitoxantrone

Answer 5

3 months
SWOG9916
TAX327

Question 6

Denosumab mech of action

Answer 6

Antibody that blocks RANKL, involved in osteoclast mediated bone resorption

Question 7

Denosumab bad side effect

Answer 7

Osteonecrosis of the jaw 1-4%

Question 8

Result of trial of abiraterone + prednisone v placebo + prednisone in pts with mCRPC after failing docetaxel

Answer 8

OS 14.8 v 10.9 mo.
PFS 5.6 v 3.6 mo
PSA response 29% v 6%