Bladder Cancer

Question 0

Most common chromosomal abnormality in TCC

Answer 0

Loss of 9q ( long arm of chromosome 9)

Question 1

Latency time for smoking and bladder cancer

Answer 1

15-20 yrs

Question 2

Most common chromosomal abnormality in SCC of the bladder

Answer 2

Alterations of 9p

Question 3

Recurrence of HG TCC at 2 years

Answer 3

80%

LG 60-70%

Question 4

Progression rate of HG TCC at 4/8 yrs

Answer 4

23%/51%

Question 5

Expected benefit of maintenance BCG

Answer 5

30% reduction of recurrences

30% decrease in progression rates

Question 6

Surveillance Cysto schedule for low risk bladder TCC

Answer 6

If initial Cysto at 3 mo is negative can wait 12 mo and then do every 6-12 mo.
If negative x5 yrs, risk of recurrence is under 5%

Question 7

What is high risk TCC

Answer 7

Any high grade (Ta, T1) and CIS.

Progression risk 25-50%

Question 8

What’s the temperature worrisome for BCG sepsis?

Answer 8

39.5 C

Under 38.5 treat sx w anticholinergic

38. 5-39.5 anticholinergic + quinolone
39. 5 needs to go to ER. Mild sepsis tx w inh. Severe 3 drugs and steroids

Question 9

Turbt shows micropapillary variant. Muscle not involved. Next step?

Answer 9

Radical cystectomy.

No chemo. No re-tur. CYSTECTOMY.

Question 10

Common immunohistochemical markers of small cell carcinoma of the bladder

Answer 10

Synaptophysin and chromogranin

Question 11

Ddx syncope with micturition

Answer 11

Paraganglioma

Pheochromocytoma

Question 12

Ddx bladder wall calcification

Answer 12

Schistosomiasis, TB, hemorrhagic cystitis, radiation cystitis, alkaline-encrusted cystitis