Prostate And Seminal Vesicles Flashcards
What are the most common fungus to infect the prostate?
Blastomycosis, coccidiomycosis, and cryptococcosis
What are postbiopsy granulomas composed of?
Central region of fibrinoid necrosis surrounded by palisading epithelioid histiocytes
How does mucous gland metaplasia differ from foamy gland metaplasia?
Foamy gland metaplasia - lumen contains pink secretions
Goblet cells - lumen with mucous
What is stage T1c adenocarcinoma of the prostate?
When cancer is found on needle core biopsy of a patient with elevated PSA
What 3 markers can be used for a poorly differentiated adenocarcinoma to confirm prostate origin?
PSA, NKX3.1, P501S
How may metastatic prostate cancer appear in the colon?
Poorly-differentiated
Sub mucosal tumor that lacks an in situ component
When are crystalloids not helpful to know if it is prostate carcinoma?
If the differential is adenosis vs low grade adenocarcinoma
What are some variants of prostate adenocarcinoma that may look like benign glands?
Atrophic variant, foamy gland carcinoma, pseudohyperplastic adenocarcinoma
What 3 features have never been seen in benign glands and are essentially diagnostic of prostate adenocarcinoma?
Peri neural invasion, mucinous fibroplasia, glomerulations
What are the common benign lesions that mimics high grade PIN?
Clear cell cribriform hyperplasia, central zone histology, basal cell hyperplasia
About 20 percent of high grade PIN harbor what fusion gene?
TMPRSS2-ERG
When should you repeat biopsy of a single core with high grade PIN? 2 or more cores
3 years
6 months
What is worse, extra prostatic extension or seminal vesicle invasion for the prognosis of prostate cancer?
Seminal vesicle invasion
What is pathological stage T1a and T1b in prostate cancer?
Those cancers incidentally found in prostate taken out for BPH
Differ the 2 by 5% rule
What is mucinous adenocarcinoma of the prostate?
When at least 25% of the tumor contains lakes of extra cellular mucin
Can only be made on radical prostatectomies
