Prostaglandins & Anti-Inflammatory Agents

Question 1

Cytokine IL-1B

Answer 1

local effects
- activates vascular endothelium
- activates lymphocytes
- increases access of effector cells

systemic effects
- fever
- production of L-6

Question 2

Cytokine TNF-a

Answer 2

local effects
- activates vascular endothelium and increases vasc permeability –> increases entry of IgG, comlement, cells to tissues
- increases fluid drainage to lymph nodes

systemic effects
- fever
- mobilization of metabolites
- shock

Question 3

Cytokine IL-6

Answer 3

local effects
- lymphocyte activation
- increased antibody production

systemic effects
- fever
- acute phase protein production

Question 4

Cytokine CXCL8

Answer 4

local effects
- chemotactic factor recruits neutrophils, basophils, and T cells to site of infection

Question 5

Cytokine IL-12

Answer 5

local effects
- activates NK cells
- induces differentiation of CD4 cells into TH1 cells