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MCM test 2 > Prokaryotic Elongation Inhibitors > Flashcards

Prokaryotic Elongation Inhibitors Flashcards

1
Q

Tetracycline

A

Binds to 30S

Blocks entry of aminoacyl-tRNA to ribosomal complex

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2
Q

Chlomarphenicol

A

Inhibition of peptidyl transferase

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3
Q

Clindamycin

A

Binds to 50S

Blocks translocation of the ribosome

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4
Q

Erythromycin

A

Binds to 50S

Blocks translocation of the ribosome

Treats pertussis

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5
Q

Streptomycin

A

Binds to 30S

Interferes with binding of fMet-tRNA

Interferes with 30S associating with 50S

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6
Q

Cycloheximide

A

Toxin from Streptomyces griseus

Inhibits peptidyl transferase in eukaryotes

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7
Q

Diphtheria toxin

A

From Corynebacterium diptheriae

Inactivated GTP bound eEF-2, interfering with ribosomal translocation (euk)

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8
Q

Shiga toxin

A

From Shigella dysenteriae
binds to large 60S SU (euk.), blocking entry of
aminoacyl-tRNA to ribosomal complex

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9
Q

Ricin

A

-Toxin from castor oil plant

-binds to large 60S SU (euk.), blocking entry of
aminoacyl-tRNA to ribosomal complex

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10
Q

Puromycin

A

From Streptomyces alboniger

Premature chain termination in both prokaryotes and eukaryotes

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MCM test 2 (3 decks)

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