Progress Test Flashcards
What do the following symptoms raise suspicion of:
self-mutilating behaviours e.g. headbanging, nail biting in someone with learning difficulties and a PMH of gout?
Lesch-Nyhan Syndrome
What are the symptoms of central retinal vein occlusion?
Sudden painless loss of vision
Severe retinal haemorrhage on fundoscopy - appearance is compared to a cheese and tomato pizza.
What metabolic derangement does pyloric stenosis cause?
Hypocholeraemic, hypokalaemic alkalosis
What does a blood film look like post splenectomy?
Howell-jolly bodies
Pappenheimer bodies
Target cells
Irregular contracted erythrocytes
What is the definition of chronic insomnia?
3 months of trouble falling asleep at least 3 nights per week
In what patient should ovarian cancer be suspected? What is the tumour marker associated?
Any older female with new onset nonspecific abdominal pain or bloating
CA125
At what age should a child be competent with a spoon and NOT spill a cup ?
2 years old
What are the symptoms of croup? Who does it typically affect and when?
Barking cough, worse at night, fever and coryzal symptoms
Presents around 2 years old and more common in autumn months
Parainfluenza is the main cause
What does herpes simplex keratitis show on fluorescein eye stain?
Dendritic ulcer
What is duodenal atresia?
neonatal bilious vomiting with a double bubble sign on abdominal xray
What is the most common cause of hepatocellular carcinoma (i) worldwide (ii) in europe?
(i) hep B
(ii) hep C
What is a common cause of tumour lysis syndrome?
Burkitts lymphoma
What is the only method of contraception which has a proven link to weight gain?
depo provera
What are the features of SVC obstruction?
Dyspnoea, swelling of face neck and arms - conjunctival and periorbital oedema
Headache, often worse in mornings
Visual disturbance
Pulseless jugular venous distension
What are the 4 stagings of ovarian cancer?
I = confined to ovary II = outside ovary but within pelvis III = outside pelvis but within abdomen IV = distant metastasis
What should be offered to woman at 34 weeks pregnancy with pre-eclampsia?
Delivery once a course of corticosteroids has been completed
What 2 diseases can exhibit genetic anticipation?
Huntington’s and myotonic dystrophy
What disease should be considered in young females who develop AKI after initiation of ACEi?
fibromuscular dysplasia
What incision is used for a pancreatectomy?
rooftop incision
What causes a subdural haemorrhage?
Damage to bridging veins between cortex and venous sinuses
What is the cause of gastroenteritis from rice?
bacillus cereus
What are axillary freckles indicative of?
Neurofibromatosis type 1
What drug can cause aplastic anaemia? What are the features of aplastic anaemia?
Phenytoin
- normocytic anaemia, leukopenia, thrombocytopenia
What features are on ECG of a patient with Wolff Parkinson White syndrome?
Short PR interval
Wide QRS with delta wave
L or R axis deviation
How do you manage bilateral adrenocortical hyperplasia?
Spironolactone
What are examples of atypical antipsychotics? What side effects can they cause?
Clozapine (agranulocytosis), olanzapine (dyslipidaemia), risperidone etc
- weight gain
What drug can cause (I) yellow green vision (ii) blue tinted vision?
(i) digoxin
(ii) sildenafil
What is a monteggia fracture?
dislocation of proximal radio-ulnar joint in association with an ulnar fracture. Commonly seen in children aged 4-10 years
Manteggia ulnar = man united
What is a Galeazzi fracture?
Fracture of distal radius with associated dislocation of distal radio-ulnar joint
Galeazzi radius = galaxy rangers
What are the 4 stages of the Keith-Wagener classification of hypertensive retinopathy?
I = arteriolar narrowing and tortuosity. Increased light reflex - silver wiring II = arteriovenous nipping III = cotton wool exudates, flame and blot haemorrhages IV = pappiloedema
What is used to reverse heparin?
Protamine sulfate
What are side effects of tricyclics?
Drowsy, dry mouth, blurred vision, constipation, urinary retention, lengthening of QT interval
What are the signs and symptoms of nasopharyngeal carcinoma?
- otalgia
- unilateral serous otitis media
- nasal obstruction, discharge and/or epistaxis
- cranial nerve palsies
- cervical lymphadenopathy
What should patients with T1DM or autoimmune thyroid disease be screened for at diagnosis?
Coeliac disease
What is the first line surgical intervention for women where uterine atony is main/only cause of haemorrhage?
Intrauterine balloon tamponade
If a woman has a small unruptured (<35mm) ectopic pregnancy with no visible heartbeat, a serum B-hCG level of <1500, no intrauterine pregnancy and no pain, what is the first line treatment?
Methotrexate
What are the different depths of burns?
SUPERFICIAL EPIDERMAL (1st degree) = red and painful
PARTIAL THICKNESS, sup dermal (2nd degree) = pale pink, painful and blistered
PARTIAL THICKNESS deep dermal (2nd degree) = typically white but may have non-blanchingerythema, reduced sensation
FULL THICKNESS (3rd degree) = white/brown/black. No blisters and no pain
What are the symptoms of Edwards syndrome?
Baby born with micrognathia, low-set ears, rocker-bottom feet and overlapping of fingers
When do people typically get otosclerosis? What are the associated symptoms?
20-40 years
- conductive deafness, tinnitus, normal tympanic membrane and positive family history
What is a typical presentation of placental abruption?
- shock out of keeping with visible loss
- pain constant
- tense, tender uterus
- normal lie and presentation
- foetal heart - absent/distressed
- coagulation problems
- beware = pre-eclampsia, DIC, anuria
What is a typical presentation of placental praevia?
- shock in proportion with visible loss
- no pain
- uterus NOT tender
- lie and presentation may be abnormal
- foetal heart = normal
- coagulation problems rare
- small bleeds before large
What is the most common cause of headache in children?
Migraine
How does lidocaine work?
blockage of Na channels
What is a cause of red eye that is NOT painful?
episcleritis
What is Kussmaul’s sign? What is the significance?
Raised JVP that doesn’t fall with inspiration
- it differentiates cardiac tamponade and constrictive pericarditis. It occurs in constrictive pericarditis
What is a key risk factor for development of avascular necrosis of femoral head?
Long term steroid use
What helps to accelerate return of normal bowel function after abdominal surgery?
epidural analgesia
What is the acute management of supraventricular tachycardia?
vagal manoeuvres e.g. valsalva
IV adenosine (verapimil in asthmatics)
electrical cardioversion
What is the treatment of primary open-angle glaucoma?
1st line = prostaglandins analogue eye drop (LANTANOPROST)
2nd line = B blocker (TIMOLOL)
3rd = laser or surgery may be tried
What is the T2DM BP target when (i) no organ damage (ii) end-organ damage present?
(i) less than 140/80 mmHg
(ii) less than 130/80 mmHg
In T1DM, what are the blood glucose targets on (i) waking (ii) before meals and other times of the day?
(i) 5-7 mmol/L
(ii) 4-7 mmol/L
What is the regime for the contraceptive patch?
Wear one patch a week for 3 weeks and don’t wear a patch on week 4
What vaccinations are required for COPD patients?
annual influenza
one-off pneumococcal
What is the difference between lichen (i) planus (ii) sclerosus?
(i) purple, pruritic, papular, polygonal rash on flexor surfaces. Wickham’s striae over surface. Oral involvement common
(ii) itchy white spots typically seen on vulva of elderly women
What is the best measure of ovulation?
measure progesterone 7 days before period
e.g. in a 28 day cycle - on day 21
on a 35 day cycle - on day 28
What does hypercalcaemia do to the QT interval?
Shortens it
What are the side effects of (i) metformin (ii) sulfonylureas (glimerpiride) (iii) glitazones (pioglitazone)?
(i) GI upset and lactic acidosis
(ii) hypos, increased appetite and weight, SIADH, liver dysfunction
(iii) weight gain, fluid retention, liver dysfunction, fractures
How would you describe basal cell carcinomas? Where are they localised to on the body?
Pearly shaped rodent ulcers with telangiectasia that do NOT metastasise
- localised to face, scalp, nose or ears
What cohort of patients are at an increased risk of developing squamous cell carcinomas?
those who are immunosuppressed
What is an indication for surgery in bronchiectasis?
localised disease
How is coeliac diagnosed?
Using IgA TTG antibodies
What is the management for degenerative cervical myelopathy?
urgently refer for assessment by specialist spinal services. Decompressive surgery is only effective treatment
What test is used to test for achilles tendon rupture?
Simmonds test
What are risk factors for ovarian cancer?
FHx = mutations of BRCA1 or 2
Many ovulations e.g. late menopause or early menarche, nullparity
- if ovarian cancer is suspected measure CA125 and if elevated perform urgent USS of abdo + pelvis
When should young people (0-24 years) be referred for immediate specialist assessment for leukaemia?
Unexplained petechiae or hepatosplenomegaly
In what population of patients are antioxidant dietary supplements NOT recommended?
smokers
- beta carotene can increase risk of lung cancer
Should pneumococcal vaccine be given before an elective splenectomy? If so, when?
Give 2 weeks before surgery
Where are diverticula most commonly found?
sigmoid colon
What are the 6 tests to confirm brain death?
pupillary reflex corneal reflex occulovestibular reflex cough reflex absent response to supraorbital pressure no spontaneous respiratory effort