Progidy- Local Anesthetics Flashcards
T/F - LA’s exert their action in the nodes of randvier
true
ATP pump =
____ K+ in
______NA++ out
2 K in,
3 NA out
Why does a nerve that’s freuqently stimulated get anesthetized quicker with a local anesthetic?
Bc the LA’s bind during the active or inactive states; so the more the nerve gets stimulated, the more chances the local anesthetic has to bind to the sodium channels .
What is the longest acting ester local anesthetic
Tetracaine
Which ester local has the shortest DOA
Chloroprocaine
opioids administered intrathecally provide analgesia through the attenuation of __fiber nociception,
C
The potential for LAST correlates with what characteristic of the drug
potency (lipid solubility)
initial signs of LAST
- agitation
- tinnitus
- circumoral numbness
- blurred vision
What is most commonly the first arrhythmia seen at toxic levels of a local anesthetic
bradycardia
When SpO2 levels are > 70%, the SpO2 will be (under/overestimated)
<70%, SpO2 will be (under/overestimated)
> 70% - underestimaded (SpO2 85%)
<70% - overestimated (Spo2 85%)
Transient neurological symptoms typically resolve within _____ days and the incidence is highest after which local anesthetic
1-7 days
lidocaine
What layer of skin is the rate-limiting layer for the absorption of eutectic mixture of local anesthetic (EMLA) cream?
A. stratum corneum
B. stratum spinosum
C. stratum granulosum
D. stratum basale
A. stratum corneum
Which local anesthetic only exists in a nonionized state?
A. tetracaine
B. benzocaine
C. procaine
D. mepivicaine
B. benzocaine
Which syndrome causes persistent paralysis of the nerves, resulting in lower extremity weakness and bladder and bowel dysfunction?
A. Cauda equina syndrome
B. Transient neurologic syndrome
C. Postdural puncture headache syndrome
D. Horner’s syndrome
A. Cauda equina syndrome
T/F: Bupivacaine can produce symptoms of cardiotoxicity at lower plasma concentrations in patients taking medications that inhibit cardiac impulse propagation such as digitalis, calcium channel blockers, or beta-blockers.
True
T/F: When clonidine is added to a LA, it prolongs the action of both long-acting and intermediate-acting agents equally
True- for up to 2 hours
Which of the following respiratory effects may occur with the administration of local anesthetics?
A. Increased bronchiolar smooth muscle tone
B. Decreased ventilatory response to hypoxia
C. Leftward shift in the CO2 response curve
D. Decreased ventilatory response to CO2
B. Decreased ventilatory response to hypoxia
Which of the following represents the standard concentration of epinephrine that would be added to a local anesthetic to prolong the duration of an epidural block? (select two)
A. 1:100,000 solution
B. 1:200,000 solution
C. 1 mcg/mL
D. 5 mcg/mL
B & D
T/F: The additional of hyaluronidase prolongs the duration of a block
false- speeds the onset by increasing the spread of local anesthetics into the tissues
All local anesthetics produce smooth muscle relaxation (vasodilation) except which 3 agents
cocaine
lido
& ropi
The duration of which local anesthetic is prolonged the most by the addition of the epinephrine?
A. Lidocaine
B. Etidocaine
C. Bupivacaine
D. Prilocaine
A. Lidocaine
T/F: the addition of epi does not significantly affect the duration of BPV
True - but perhaps people use it to decrease risk for toxicity by decreasing vascular uptake of the drug ?