progestins and antiprogestins.

Question 1

progesterone physiology

Answer 1

1) endometrial maturation secretory phase.
2) maturation and proliferation of breast- secretory phase.
3) maintanance of pregnancy.
4) increased temp.
5) fat deposition and carbohydrate metabolism chance.
6) increased ventilation and more.

Question 2

kinetics of progesterone

Answer 2

I.M adminstration since first pass metabolism is high.

Question 3

synthetic- pregans- 21carbon names

Answer 3

1. medroxyprogesterone- acetate.
2. hydroxyprogesterone-capronate.
3. megestrol-acetate.
4. drospirenone.

Question 4

synthetic 19c- estrans

Answer 4

1. norethisterone
2. norethynodrel
3. ethynodiol
4. lynestrenol.
   may cause virilization

Question 5

gonans-13ethyl deriv.

Answer 5

norgestrel
levonorgestrel
desogestrel
norgestimate

Question 6

indicated:

Answer 6

1. primary hypogonadism
2. postmenopausal hormone therapy
3. hormonal contra
4. long term ovarian supression (Dysmenorrhea, endometriosis, bleeding disorders when estrogen are contra).
5. prevention of preterm birth.
6. palliative treatment of estrogen depdent tumors.
7. medoxyprogesterone- prevent mesturation.

Question 7

adverse

Answer 7

1, increasd risk for breast cancer.

2. decreased HDL
3. glucose intolerance.
4. psychic state and headaches.
5. BP increase.
6. anabolic effects.

Question 8

antiprogestin

Answer 8

1. mifepristone (RU486)- abortive drug
   MOA: progesterone antagonist with partial agonist activity.
   administration in early pregancny.
   usually combined with misoprostol (prostaglandin anlog) given orally or vaginllay.
   adverse- uterine bleed, imcomplete abortion and vomit.
2. ulipristal- morning after pill.
   used to treat myomas.