Progestin Contraceptives Flashcards

1
Q

CONS of Progestins

A

-

-Increase LDL levels

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2
Q

PROS of Progestins

A

-

-Increases quality and duration of lactation

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3
Q

First-Generation Progestins

A
  • Norethindrone
  • Norethindrone acetate
  • Ethynodiol diacetate

MOA = Has affinity for progesterone and androgen receptors (at lower affinity than 2nd generations)

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4
Q

Second-Generation Progestins

A
  • Norgestrel
  • Levonorgestrel

MOA= Has affinity for progesterone and androgen receptors (higher affinity than 1st generations)

  • Less breakthrough bleed or spotting d/t higher affinity for progesterone receptors
  • May cause more acne, hirsutism, dyslipidemia, weight gain b/c higher affinity for androgen receptors
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5
Q

Third-Generation Progestins

A
  • Norgestimate
  • Desogestrel

MOA = Lower activity on androgen receptors. Also binds to progesterone receptors

-Less androgenic side effects (Acne, DLP, wt gain, hirsutism)

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6
Q

Other New Progestins

A
  • Drospirenone
  • Dienogest

MOA = Binds primarily to progesterone receptors with little to no affinity for other steroid receptors. Possible anti-androgen effects

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7
Q

Signs of “TOO MUCH” Progestin

A
  • Breast tenderness
  • Headache
  • Fatigue
  • Mood changes
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8
Q

Signs of “TOO LITTLE” Progestin

A

-Breakthrough bleeding in late cycle

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9
Q

Progestin-only Pills (POPs) “minipills”

A

Available as “Norethindrone 350 mcg (Micronor, Jencycla)

  • Short half-life, so if taken more than 3 hrs late, it can increase risk of pregnancy (use backup contraceptive)
  • No hormone-free days
  • PRO = Less bleeding during menstruation
  • CON = More irregular/unpredictable breakthrough bleeding/spotting
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