Prodrug/Active Ingredient

Question 1

Capecitabine

Answer 1

Fluorouracil

Question 2

Clopidogrel

Answer 2

CYP2C19

Question 3

Codeine

Answer 3

Morphine
CYP2D6

Question 4

Colistimethate

Answer 4

Colistin

(same this as polumyxin E) last line for gram negative infections

Question 5

Cortisone

Answer 5

Cortisol

Question 6

Famciclovir

Answer 6

Penciclovir

topical for cold sores from herpes simplex virus

Question 7

Fosphenytoin

Answer 7

Phenytoin

1 mcg/mL PE = 1.5 mcg/mL FosPE

Question 8

Isavuconazonium sulfate

Answer 8

Isavuconazole

greatest risk of QTc prolongation

Question 9

Levodopa

Answer 9

Dopamine

Question 10

Lisdexamgetamine

Answer 10

Dextroamphetamine

Question 11

Prednisone

Answer 11

Prednisolone

Question 12

Primidone

Answer 12

Phenobartbital

Question 13

Tramadol

Answer 13

something

Question 14

Valacyclovir

Answer 14

Acyclovir

Question 15

Valganciclovir

Answer 15

Ganciclovir

Question 16

Common CYP inhibitors

Answer 16

Grapefruit
Protease Inhibitors (Ritonavir)
Azoles
Cyclosporine, Cobicistat
Macrolides (NOT azithromycin)
Amiodarone
Non-DHP CCBs

Question 17

Common CYP inducers

Answer 17

St John’s Wart
Phenytoin
Smoking
Phenobarbitol
Carbamazepine/Oxcarbazepine
Rifampin