Prodrug/Active Ingredient Flashcards

1
Q

Capecitabine

A

Fluorouracil

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2
Q

Clopidogrel

A

CYP2C19

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3
Q

Codeine

A

Morphine
CYP2D6

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4
Q

Colistimethate

A

Colistin

(same this as polumyxin E) last line for gram negative infections

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5
Q

Cortisone

A

Cortisol

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6
Q

Famciclovir

A

Penciclovir

topical for cold sores from herpes simplex virus

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7
Q

Fosphenytoin

A

Phenytoin

1 mcg/mL PE = 1.5 mcg/mL FosPE

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8
Q

Isavuconazonium sulfate

A

Isavuconazole

greatest risk of QTc prolongation

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9
Q

Levodopa

A

Dopamine

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10
Q

Lisdexamgetamine

A

Dextroamphetamine

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11
Q

Prednisone

A

Prednisolone

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12
Q

Primidone

A

Phenobartbital

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13
Q

Tramadol

A

something

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14
Q

Valacyclovir

A

Acyclovir

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15
Q

Valganciclovir

A

Ganciclovir

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16
Q

Common CYP inhibitors

A

Grapefruit
Protease Inhibitors (Ritonavir)
Azoles
Cyclosporine, Cobicistat
Macrolides (NOT azithromycin)
Amiodarone
Non-DHP CCBs

17
Q

Common CYP inducers

A

St John’s Wart
Phenytoin
Smoking
Phenobarbitol
Carbamazepine/Oxcarbazepine
Rifampin