Principles of Pharmacology

Question 1

What is directly correlated to the effect a drug has on a body?

Answer 1

Plasma Concentration (Cp)

Question 2

When graphing a single dose curve, what are some of the important things to notice?

Answer 2

1. Onset of effect (what is the lag time before the drug takes effect)
2. Duration of Action
3. Therapeutic Window (Window between therapeutic and toxic concentrations of drug)

Question 3

The primary goal of pharmacology when multiple doses are administered is to:

Answer 3

Reach and maintain the plasma concentrations of a drug at steady state.

Question 4

What are the basic elements of a dosage regimen?

Answer 4

Drug: Tylenol
Dose: 500 mg
Route: orally
Frequency: 3x day
Duration: as long as needed

Question 5

What is the difference between a side effect, extension effect, and idiosyncratic effect?

Answer 5

Side effect- Seen at therapeutic doses where non target systems are effected.

Extension effect- Seen at higher doses on target systems

Idiosyncratic effect- reactions particular to the individual (allergies and metabolic problems)