Elimination

Question 1

How are half life of a drug and clearance related?

Answer 1

Inversely

Question 2

How are half life of a drug and volume of distribution related?

Answer 2

Directly

Question 3

Which two organs are responsible for clearance of a drug?

Answer 3

Liver (fat soluble) and Kidney (water soluble)

Question 4

Elimination of a constant FRACTION (per cent) of drug per unit of time is:

Answer 4

1st order elimination

Question 5

Elimination of a constant AMOUNT of drug per unit of time is:

Answer 5

0 order elimination

Question 6

A drug which has a low volume of distribution means most of the drug remains in the_____________

Answer 6

Plasma

Question 7

A drug with a high Vd means most of the drug leaves the ___________ and concentrates __________.

Answer 7

A drug with a high Vd means most of the drug leaves the PLASMA and concentrates “ELSEWHERE”.

Question 8

What is the fluctuation of a drug that has a half life of 6 hours and a dose of 500mg when given every 12 hours?

Answer 8

4.

2^n where n=# of half lives.