Principles of pharmacology

Question 1

What 4 parts is pharmacokinetics split up into?

Answer 1

1. absorption
2. distribution
3. metabolism
4. excretion

Question 2

What are the routes of administration?

Answer 2

1. enteral (into GI)
2. topical (eptihelial surfaces)
3. parenteral (injections)

Question 3

What needs to be taken into account when administering drugs to cattle via oral route?

Answer 3

volume of rumen is 50L, so big dilution factor

Question 4

Disadvantage of administering drug orally

Answer 4

• effect of drug will be slow
• gut may break down some of the chemicals in the drug

Question 5

What does absorption and distribution cover?

Answer 5

• translocation
• pH and ion trapping
• plasma protein binding
• partition into body fat
• body fluid compartments
• BBB
• Vd

Question 6

What 2 ways can drugs be translocated?

Answer 6

1. Bulf flow transfer - injected into vein
2. diffusional transfer - through lipid/aqueous pores