Principles of pharm Flashcards
Define Pharmokinetics
Study of how a drug is absorbed, distributed or eliminated from the body
Define Pharmodynamics
Analysis of what the drug does to the body at the systemic and cellular level
What are the 3 different name a drug can have?
Trade or brand name
Generic
Chemical
How does the brand name compare to the generic name?
Brand name is assigned by the pharmaceutical company manufacturer the drug (can have more than one depending on how many manufacturers there are) while the generic name is based off the chemical name
A doctor prescribes a drug that is primarily used for seizures for a different cause. The term to describe this is:
off label prescribing
What information does a dose response curve provide?
Provides information about the dosage range where the drug is effective
T/F Threshold dose is the dose above the level will not result in further change
False: Ceiling effect or maximum dose
Threshold dose is the minimum dose required to create cellular change
If you have two drugs: A and B. Drug A produces an affect at a much lower dose than drug B. Which drug is more potent?
Drug A
Define half life
The amount of time required for 50% of the drug in the body to be eliminated
Define tolerance
Prolonged use of a drug induces the body to adjust and enzymatically destroy the drug more rapidly = enzyme induction
Median Effective Dose
The concentration of the drug at which 50% of the population respond to it in the expected manner
Medican toxic dose
As the dose is continuously increased more and more people will have an adverse effect (50% of people)
Median lethal dose
The dose that causes death in 50% of the animals it was tested on
Therapeutic Index
Determined by the median effective dose and the toxic doses (TI = TD50/ED50)
What is a large TI mean compared to a small TI
A large TI indicates that it takes a much larger dose to evoke a toxic response than it does to create a beneficial one
