Principles Of Pharacology Flashcards
What reference governs the prescribing medications?
MANMED/NAVMED P-117, Chapter 21
How do prescribers place orders?
Via
* TMIP/Genesis
* DD1289
* NAVMED 6710/6
When is a 1289 required to be filled out?
When prescribing controlled drugs or directed by the CO or higher authority.
What is the study of drug absorption, distribution, metabolism, and excretion known as?
Pharmacokinetics
Carrier molecule such as a protein or enzyme that activate lay moves the drug across the membrane describes what?
Active Absorption
Diffuse across a membrane from area of higher concentration to an area of lower concentration describes what?
Passive absorption
What is Pinocytosis?
When the cell engulfs the drug particle across the cell membrane.
I.e. Pac-man
What is bioavailability?
The percentage of administered drug dose that reaches the systemic circulation.
* Think of it as the effectiveness of a medication by it Route of administration.
What factors affects bioavailability?
- The form of the medication
- Route of administration
- Changes in liver function
- GI Mucosa and motility
- Food and drugs
- Solubility
Where does metabolism occur?
In the liver, kidneys, lungs, plasma, and intestinal mucosa.
What is a agonist?
A drug that binds with a receptor to produce the therapeutic response.
What is an Antagonist?
Drug that binds to receptor stronger than the agonist thus producing no pharmacological effect.
* Narcan is an agonist to morphine.
What are the factors that may affect the actions of drugs?
- Age
- Weight
- Gender
- Disease
- Route of administration
How many drug ratings categories exist for pregnancy?
- There is 5 which includes;
- A- Controlled human studies show no risk
- B- No evidence of risk in studies
- C- Risk cannot be ruled out
- D- Positive evidence of risk
- X- Contraindicated in pregnancy
