Principles Of Metabolism

Question 0

MELAS

Answer 0

Mutation in mitochondrial DNA

Inefficiency in proton pumping –> reduces yield of ATP

Question 1

Leber’s hereditary optic neuropathy

Answer 1

Degeneration of optic nerve and increasing blindness
Mitochondrial disease
NADH-CoQ reductase –> missense mutation –> subunit 4 change