Glucose Metabolism

Question 0

Malignant hypothermia

Answer 0

Life-threateningly high body temperature

Futile cycling of phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate

Question 1

Pyruvate kinase deficiency

Answer 1

Autosomal recessive
Enzyme to have low affinity for phosphoenolpyruvate –> thermally unstable + lower inhibition constant for ATP
Chronic haemolytic anaemia (red blood cell destruction)

Question 2

Untreated Type I Diabetes mellitus

Answer 2

Net mobilisation of glycogen –> gluconeogenesis –> exceedingly high blood glucose conc.

Question 3

Maternal hypoglycaemia

Answer 3

In pregnancy, when foetal glucose demand is high

Question 4

Fructose intolerance

Answer 4

Affecting glucokinase (liver)
Absence of end-product inhibition --> large quantities of F-6-P generated --> can't be metabolised further --> liver ATP levels drop --> compromising hepatocyte cellular function

Question 5

Lactic acid build up

Answer 5

Lowers pH

Especially likely when blood flow inadequate : extreme exercise, angina pectoris attack