Principles of Leukopenia and Leukocytosis Flashcards

1
Q

leukopenia

A

=decrease WBC
* neutropenia: CTX, severe infection
TX: CM-CSF, or G-CSF
* Lymphopenia: DiGeorge, no fxnl thymus, high cortisol, SLE, radiation

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2
Q

leukocytosis

A

= increase WBC

  • Neutrophilic leukocytosis
  • monocytosis
  • Eosinophilia
  • Basophilia
  • Lymphocytic leukocytosis
  • Infectious mononucleosis
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3
Q

normal WBC count

A

5-10K

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4
Q

neutrophilic leukocytosis

A

D/t bacterial infection or tissue necrosis
left shift
decrease FcR and CD16+
high cortisol disrupts margination

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5
Q

monocytosis

A

chronic inflammatory state, bacterial endocarditis, rickettsiosis, malaria, autoimmune, IBD
malignancy

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6
Q

eosinophlia

A

allergic rxns
parasitic infection - helminthic
HL - IL-5 production

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7
Q

basophilia

A

ax w/ CML, myeloproliferative dz

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8
Q

lymphocytic leukocytosis

A

viral infections, chronic immunologic stim

Bordatella pertussis

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9
Q

infectious mononucleosis

A

reactive T-cells
EBV infection–> lymphocytic leukocytosis comprised of reactive CD8+ T cells
EBC –> hyperplasia of paracortex
splenomegaly, periarterial lymphatic sheath of WHITE pulp
Monospot test(+)
if (-) –> CMV

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