Principles of Leukopenia and Leukocytosis Flashcards
leukopenia
=decrease WBC
* neutropenia: CTX, severe infection
TX: CM-CSF, or G-CSF
* Lymphopenia: DiGeorge, no fxnl thymus, high cortisol, SLE, radiation
leukocytosis
= increase WBC
- Neutrophilic leukocytosis
- monocytosis
- Eosinophilia
- Basophilia
- Lymphocytic leukocytosis
- Infectious mononucleosis
normal WBC count
5-10K
neutrophilic leukocytosis
D/t bacterial infection or tissue necrosis
left shift
decrease FcR and CD16+
high cortisol disrupts margination
monocytosis
chronic inflammatory state, bacterial endocarditis, rickettsiosis, malaria, autoimmune, IBD
malignancy
eosinophlia
allergic rxns
parasitic infection - helminthic
HL - IL-5 production
basophilia
ax w/ CML, myeloproliferative dz
lymphocytic leukocytosis
viral infections, chronic immunologic stim
Bordatella pertussis
infectious mononucleosis
reactive T-cells
EBV infection–> lymphocytic leukocytosis comprised of reactive CD8+ T cells
EBC –> hyperplasia of paracortex
splenomegaly, periarterial lymphatic sheath of WHITE pulp
Monospot test(+)
if (-) –> CMV