Chronic Leukemia

Question 1

CLL

Answer 1

chronic lymphocytic leukemia
neoplastic prolif of naive B-cells
increased lymphocytes and smudge cells
small lymphocytic lymphoma
hypogammaglobulinemia
autoimmune hemoytic anemia
transformation to DLBCL
enlarging lymph node and spleen

Question 2

Hairy Cell Leukemia

Answer 2

mature B cells --> memory B cell
hairy cytoplasmic processes
TRAP (+)
splenomegaly - RED pulp
sensitive to CTX
CD25+, PAX5, CD11c+, CD103+

Question 3

ATLL

Answer 3

adult T-cell leukemia lymphoma
neoplastic prolif of mature CD4+ T cells, helper T-cells
HTLV-1 –> Japan and Carribean
rash; LAD w/ HSM, Lytic bone lesions

Question 4

Mycosis Fungoides

Answer 4

neoplastic prolif of mature CD4+ T cells
rash, plaques, or nodules
Pautrier microabscesses
Sezary syndrome - exfoliative erthroderma all over body, whereas Mycosis fungoides is more localized
Cerebriform nuclei