Principles of immunity

Question 1

The immune system divided into 2 functional divisions

Answer 1

Innate (natural)

Adaptive (acquired)

Question 2

Non specific (innate) immunity characteristics

Answer 2

response is antigen independant
immediate maximal response
not antigen specific
no immunological memory

Question 3

Specific (adaptive) immunity characteristics

Answer 3

antigen dependant
lag time
antigen specific
immunlogical memory

Question 4

What does the non specific (adaptive) system contain?

Answer 4

Skin
GI tract
Lung
eye
serum

Question 5

whats the major non specific (adaptive) defence mechanism?

Answer 5

humoral immunity

Question 6

what cells are in the adaptive immune system

Answer 6

WBC (B + T)

Antigen presenting cells

Question 7

what are 2 principles of clonal selection hypothesis?

Answer 7

1. each lymphocyte bears a single type of receptor of unique specificity
2. Lymphocytes which recognise self molecules are deleted at an early stage of lymphocyte development

Question 8

What is the clonal selection hypothesis?

Answer 8

1. a single progenitor cell gives rise to a large number of lymphocytes, each with a different specificity
2. removal of self reactive immature lymphocytes by clonal delection
3. Pool of mature naive lymphocytes
4. Proliferation and differentiation of activated specific lymphocytes to form a clone of effector cells

Question 9

Two classes of the specific (adaptive) immune response?

Answer 9

1. Antibody response (Humoral)(B lymphocytes)

2. Cell mediated (T cells)response

Question 10

Cytotoxic cell activation process?

Answer 10

1. Tc-cells have antigen-recognising molecules on thier surfaces called T-cell receptors (TCR)
2. Th cells produce cytokines(e.g IL-2,IFN)
3. IL-2 causes Tc-cells to mature, divide

Question 11

What can Cytotoxic T cells become?

Answer 11

• cytotoxic t cells, that kill abnormal cells

- memory cytotoxic T cells