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THER 201 2nd Exam > Principles of Drug Interaction & Adverse Drug Reactions > Flashcards

Principles of Drug Interaction & Adverse Drug Reactions Flashcards

1
Q

substrate
inhibitor
inducer

cyp1a2

A

substrate - warfarin
inhibitor - cimetidine
inducer - phenytoin

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2
Q

substrate
inhibitor
inducer

cyp2b6

A

substrate - bupropion
inhibitor - thiotepa
inducer - rifampin

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3
Q

substrate
inhibitor
inducer

cyp2c9

A

substrate - phenytoin
inhibitor - isoniazid
inducer - rifampin

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4
Q

substrate
inhibitor
inducer

cyp2c19

A

substrate - diazepam
inhibitor - ketoconazole
inducer - n/a

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5
Q

substrate
inhibitor
inducer

cyp2d6

A

substrate - metoprolol
inhibitor - cimetidine
inducer - n/a

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6
Q

substrate
inhibitor
inducer

cyp2e1

A

substrate - ethanol
inhibitor - disulfiram
inducer - inh (isoniazid)

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7
Q

substrate
inhibitor
inducer

cyp3a4, 5, etc

A

substrate - terfenadine
inhibitor - erythromycin
inducer - phenytoin

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8
Q

torsades de pointes

A

terfenadin + erythromycin

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9
Q

cimetidine inhibits which enzymes (2)

A

cyp1a2, cyp2d6

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10
Q

phenytoin induces which enzymes (2)

A

cyp1a2, cyp3a4/5/etc

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11
Q

rifampin induces which enzymes (2)

A

cyp2b6, cyp2c9

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12
Q

potent inhibitors

A

H(ate) 2 B(a)RF INHIm

H2Blockers (CIMETIDINE)
Ritonavir
Fluoroquinolones (ciprofloxacin)
INH
Imidazole (fluconazole)

[cip cim con INH rit]

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13
Q

potent inducers

A

CPR my phenytoin hahah

carbamazepine
phenobarbital
phenytoin
rifampin

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14
Q

H1 blockers

A

terfenatine
astemizole
loratadine

[ter ast lor]
ter, ast the lor on h1 (high)

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15
Q

H2 blockers

A

cimetidine
ranitidine
famotidine

[cim ran fam]
cim ran from her fam, sounds like tidine

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16
Q

beta blockers

A

propranolol
atenolol
metoprolol

[pro aten meto] heart block

17
Q

macrolides

A

clarithromycin
erythromycin
azithromycin

[clar ery azith] utilize 3a4
cea

18
Q

antifungals

A

ketoconazole
itraconazole
fluconazole

[keto itra flu] inhibit 3a4

19
Q

ca channel blockers

A

verapamil
nifepidine
carvedilol

[ver nif car] heart block
very nife (lithp) car Ca
20
Q

grapefruit has _ that inhibits cyp3a4; thus increasing what?

A

furanocoumarins

statins, ccb

21
Q

food high in vitamin k such as _ inhibits _

A

grean leafy veggies inhibits blood thinning drugs

22
Q

from black licorice, affects digoxin MOA?

A

glycyrrhiza

deplete K
inc Na retention

23
Q

inc bp, prevents bkdown of MAO inhibitors

A

tyramine foods (e.g. chocolate, cheese, hot dog)

THER 201 2nd Exam (2 decks)

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