Principles of Drug Interaction & Adverse Drug Reactions Flashcards
substrate
inhibitor
inducer
cyp1a2
substrate - warfarin
inhibitor - cimetidine
inducer - phenytoin
substrate
inhibitor
inducer
cyp2b6
substrate - bupropion
inhibitor - thiotepa
inducer - rifampin
substrate
inhibitor
inducer
cyp2c9
substrate - phenytoin
inhibitor - isoniazid
inducer - rifampin
substrate
inhibitor
inducer
cyp2c19
substrate - diazepam
inhibitor - ketoconazole
inducer - n/a
substrate
inhibitor
inducer
cyp2d6
substrate - metoprolol
inhibitor - cimetidine
inducer - n/a
substrate
inhibitor
inducer
cyp2e1
substrate - ethanol
inhibitor - disulfiram
inducer - inh (isoniazid)
substrate
inhibitor
inducer
cyp3a4, 5, etc
substrate - terfenadine
inhibitor - erythromycin
inducer - phenytoin
torsades de pointes
terfenadin + erythromycin
cimetidine inhibits which enzymes (2)
cyp1a2, cyp2d6
phenytoin induces which enzymes (2)
cyp1a2, cyp3a4/5/etc
rifampin induces which enzymes (2)
cyp2b6, cyp2c9
potent inhibitors
H(ate) 2 B(a)RF INHIm
H2Blockers (CIMETIDINE) Ritonavir Fluoroquinolones (ciprofloxacin) INH Imidazole (fluconazole)
[cip cim con INH rit]
potent inducers
CPR my phenytoin hahah
carbamazepine
phenobarbital
phenytoin
rifampin
H1 blockers
terfenatine
astemizole
loratadine
[ter ast lor]
ter, ast the lor on h1 (high)
H2 blockers
cimetidine
ranitidine
famotidine
[cim ran fam]
cim ran from her fam, sounds like tidine
beta blockers
propranolol
atenolol
metoprolol
[pro aten meto] heart block
macrolides
clarithromycin
erythromycin
azithromycin
[clar ery azith] utilize 3a4
cea
antifungals
ketoconazole
itraconazole
fluconazole
[keto itra flu] inhibit 3a4
ca channel blockers
verapamil
nifepidine
carvedilol
[ver nif car] heart block very nife (lithp) car Ca
grapefruit has _ that inhibits cyp3a4; thus increasing what?
furanocoumarins
statins, ccb
food high in vitamin k such as _ inhibits _
grean leafy veggies inhibits blood thinning drugs
from black licorice, affects digoxin MOA?
glycyrrhiza
deplete K
inc Na retention
inc bp, prevents bkdown of MAO inhibitors
tyramine foods (e.g. chocolate, cheese, hot dog)