Intro to Herbal Medicine Research and Development Flashcards
What is required/not required of herbal/food supplements in the Philippines?
Only evidence of safety is required;
no evidence of efficacy required.
Traditionally used herbal products, as defined by the Philippine FDA, are preparations whose claimed application is based on what?
Based only on the experience of long usage (at least 5 decades) as documented in medical, historical, and ethnological lit
T/F
Traditionally used herbal products require much evidence for safety and efficacy.
F, minimal lungs. :) - Phil FDA 2004 Guidelines
- Documentation of prolonged and permanent uneventful use
- Absence of potential for systematic toxicity, carcinogenicity, and teratogenicity
- Evidence for claimed application shall be based on medical/pharmaceutical lit
Required phases for galenicals vs dosage forms
galenicals - phase 1
dosage forms - 1, 2, 3
Artemisia annua
Leaf tea used to treat what?
Isolated active principle?
Malaria
Artemisine
The isolated active principle in Artemisia annua is enhanced by?
Flavonoids artemetin and casticin, which in itself have no malarial activity
Salicin source? What does it affect?
Salix alba
COX2
Salicin synergists?
Flavonoids and tannins
6 herbal medicines developed by NIRPROMP
Sambong Ampalaya Akapulko Lagundi Tsaang Gubat Yerba Buena
Aspirin
Source Plant?
Indication?
Irreversible inactivation of COX, dec PG, TXA2
Salix alba - white willow
fever, pain, inflammation, kawasaki
prevents thromboembolism
Oseltamivir
Source Plant?
Indication?
Inhibits neuraminidase
Illicium vera - star anise
influenza A and B
Atropine
Source Plant?
Indication?
Inhibits muscarinic Ach
Atropa belladonna
overdose of cholinergic and organophosphate pesticides
bradycardia
Tiotropium bromide
Source Plant?
Indication?
Inhibits muscarinic Ach
Atropa belladona
bronchospasm, COPD
Metformin
Source Plant?
Indication?
Reduce hepatic glucose production, renal gluconeogenesis
Galega officinalis - french lilac
DM 2
Artemether
Source Plant?
Indication?
Inhibits Ca2+ dependent ATPase
Artemisia annua - qinghasu
Chloroquine-resistant P. falciparum
