principles neurology Flashcards
away from CNS
efferent
towards CNS
arrerent
what is a ganglion
a group of nerve cell bodies that house synapses
route of parasympathetic nerves
cranium - sacrum
parasympathetic cranial nerves
CN3, 7, 9, 10
parasympathetic neurotransmitter
ACh
parasympathetic receptor
nicotinic
short post ganglionic
ACh neurotransmitter, Muscularinic receptor
functions of the parasympathetic division
slow HR, lower BP, arousal, salivation, lacrimation, urination, digestion and defecation
short preganglionic fibre of sympathetic is from
thoracolumbar
preganglionic sympathetic receptor and neurotransmitter
ACh and nicotinic receptor
long post ganglionic symapthetic
NA nuerotransmitter activates G protein coupled adrenics
functions of the sympathetic system
increases HR and force, reduces GI motility, contrictionof sphinters, vasoconstriction but relaxation in skeleatl muscle adrealine release from the adrenal galnd, ejaculation, relaxes bronchi and decreases mucus production
preganglionic nicotinic cholinergic
central cation conducting ligand gated channel
post ganglionic muscarinic
activated by G protein receptors
g protein of M1
Gq
effect of M1
increased gastric acid secretion
g protein of m2
Gi
effect of M2
decreased HR
G protein of m3
GQ
effect of M3
increased salvary secretion and bronchial smooth muscle contraction
sympathetic nicotinic cholinergic
5 glycoprotein subunits form a central cation conducting channel activated by lingand gated cahnenls
noradrenaline trasnmission
adrenoceptor activation, NA reuptake by transporters u1 and U2
metabolism of NA
monoamine oxidase MAO and catechol-O-methyltransferase COMT
beta 1 receptor effect
increased HR and force
beta 2 receptor effect
bronchial and vascular smooth muscle relaxation
alpha 1 receptor g protein
Gq
alpha 2 receptor g protein
Gi
alpha 1 receptor effect
vascular smooth muscle contraction
alpha 2 receptor effect
inhibits NA release
cocaine effect of ANS
adrenoceptor stimulation, peripheral vasoconstriction a1 and cardiac arrhytmias b1
amphetamine effect on ANS
adrenoceptor stimulation same as concaine ( constricts and causes cardiac arrhytmias
effect of atenolol on ANS
selective competitive antagonist of b1 adrenoceptors
effect of atropine on ANS
competitive muscularinic ACh receptor antagonist - blocks parasympathetic stimulation