Principles Exam I Flashcards
Supraventricular Tachycardia (unstable)
[signs]
systolic blood pressure < 80
(if no pulse, go to PEA event)
Supraventricular Tachycardia (unstable)
[treatment]
- 100% oxygen
- synchronized cardioversion
- narrow and regular: 50-100J
- narrow and irregular: 120-200J
- wide and regular: 100J
- wide and irregular: 200J unsynchronized
- Consider Adenosine 6mg if narrow and regular
Supraventricular Tachycardia (stable)
[treatment]
- 100% oxygen
- 12-lead EKG
- place A-line and check ABG
- consider stat cardiology consult
which type of SVT should you prepare to defibrillate
wide and irregular
Which type of SVT should you give Amiodarone only?
wide and regular
(may also consider procainamide or sotalol)
Which beta blockers can be used for narrow complex SVTs?
Esmolol - 0.5 mg/kg over 1 min
Metoprolol - 1.0 - 2.5 mg
Which calcium channel blocker may be sued for narow complex SVTs?
amiodarone
150 mg IV over 10 minutes
Bronchospasm
[treatment]
- 100% oxygen
- lengthen expiratory time
- deepen volatile agent
- rule out mainstem or kinked ETT
- Albuterol +/- Ipatropium
- epineprhine
- ketamine 0.2-1.0 mg/kg
- hydrocortisone 100mg
- nebulized racemic epi
Hypotension
[differential diagnosis]
- decreased preload
- low SVR
- decreased contractility
- low HR
hypotension
[rule out these first]
- hemorrhage
- anesthetic overdose
- auto-PEEP
- pneumothorax
- anaphylaxis
- MI, low EF, mitral valve
- pneumoperitoneum
- IVC compression
hypoxemia
[differential diagnosis]
- hypoventilaiton
- low FiO2
- V/Q mismatch or shunt
- diffusion problem
- increased metabolic O2 demand
Dantrolene for MH
[dose and concentration]
2.5 mg/kg
dilute each 20mg dantrolene vial in 60 mL sterile water
Malignant Hyperthermia
[differential diagnosis]
- light anesthesia
- hypoventilation
- insufflaiton of CO2
- over-heating
- hypoxemia
- thyroid storm
- pheochromocytoma
- neuroleptic malignant syndrome
- serotonin syndrome
Pneumothorax
[signs]
- tachycardia
- hypotension
- hypoxemia
- decreased breath sounds
- hyperresonance of chest to percussion
- tracheal deviation
- increased JVD/CVP
Pneumothorax
[treatment]
14 or 16 gauge needle mid-clavicular 2nd intercostal space
most common problem leading to cardiac transplant
end-stage cardiac failure from:
ischemic or idiopathic cardiac dilated cardiomyopathy
(4) bridges to heart transplant
- intravenous inotropes
- intra-aortic balloon pump
- ventricular assist devices
- mechanical ventilation
what (2) factors may preclude a patient’s eligibility for heart transplant?
increased PVR
(wood units > 6)
Surgical stages of Heart transplant
- sternotomy
- cannulaiton before bypass
- CPB when donar heart arriveds
- systemic cooling
- explanted heart excised
- withdraw CVP or PAC when heart is removed
- anastomosis of aorta, pulmonary artery, right atria, and left atria
- IV corticosteroids prior to unclamping
- prepare for separation from bypass
*
what inotropic agents can be used with a transplanted heart?
- dopamine
- dobutamine
- epinephrine
- norepinephrine
target heart rate after separation from bypass
90 - 110 beats/min
(3) Post-bypass priorities
- correction of coagulopathy
- maintaine circulatory stability
- maintain temp, electrolytes, and acid-base
most common cause of death in kidney transplant patients
infection
Other than infection, what else is at increased risk in transplant patients?
cancer
due to chronic immunosuppresion
graft survival in cadaveric kidney
65% at 5 yearws
living donor kidney survival
80% in 5 years
(4) Major indications for Kidney transplant
diabetes
hypertension induced neuropathy
glomerulonephritis
polyscytic kidney disease
Hematologic problems associated with ESRD
- anemia
- platelet dysfunction
- coagulopathies
- increased capillary fragility
neurologic problems associated with ESRD
peripheral and autonomic neuropathy
Gastrointestinal problems associated with ESRD
- impaired gastric emptying
- gastroparesis
- nausea
- vomitting
- anorexia
- peptic ulcer disease
endocrine problems associated with ESRD
- hyperparathyroidism
- osteodystrophy
- impaired growth and development
- glucose intolerance
pulmonary problems associated with ESRD
- pneumonia
- pulmonary edema
- pleuritis
- atelectasis
hepatic problems associated with ESRD
- hypoalbuminemia
- cytochrome P450 abnormality
- hepatitis
CVP should be maintained between _____ in renal patients
10 - 15 mmHg
(3) drugs that should be avoided in renal patients due to decreased renal elimination
pancuronium, morphine, and meperidine
50% of post-transplant of kidneys are related to ____ problems
cardiac
detection of CAD prior to transplantation is vital
diabetics are at increased risk of ______ after a kidney transplant
hypotension, bradycardia, and sudden death
diabetics require hourly monitoring of blood glucose
systolic blood pressure goal during graft reperfusion
130-140 mmHg
A-I of liver functions
A - albumin
B - bile
C - coagulation
D - drug metabolism
E - elimination
F - fat metabolism
G - gluconeogensis
H - hormones
I - immunologic
drug given to end-stage liver with encephalopathy
lactulose
given to clear ammonia
Wilson’s Disease
copper accumulation
Below what albumin level indicates the liver is not functioning well?
below 3
Common causes of End-stage liver disease
- chronic hepatitis (B or C)
- alcoholic cirrhosis
- cholestatic cirrhosis
(2) patient classification for liver disease
Child-pugh and model of ESLD (MELD)
MELD is more common and evaluates creatinine, bilirubin, and INR
CNS problems associated with end-stage liver
hepatic encephalopathy
increased intracranial pressure
cardiac complications associated with end-stage liver
hyperdynamic circulation
cirrhotic cardiomyopathy
respiratory complications associated with end-stage liver
hepatopulmonary syndrome
portopulmonary hypertension
GI complications associated with end-stage liver
portal hypertension
upper GI bleeding
ascites
hematologic complications associated with end-stage liver
- anemia
- thrombocytopenia
- prolonged PT and PTT
- decreased plasma fibrinogen
- DIC
- protein C and S deficiency
renal complications associated with end-stage liver
hepatorenal syndrome
acute tubular necrosis
surgical phases of liver transplant
preanhepatic (dissection)
anhepatic
neohepatic (reperfusion)
Anhepatic phase of liver transplant
- vascular anastomosis
- veno-veno bypass used sometimes to minimize decreases in preload and CO
Criteria for diagnosis of brain death
- loss of cerebral function
- no spontaneous movement
- unresponsive to external stimuli
- loss of brainstem function
- apnea
- absent cranial nerve reflexes
- supporting documentation
- EEG
- cerebral blood flow studies
Surgical steps in Organ procurement
- chest and abdomen open
- aorta and IVC are dissected
- 30,000 units of Heparin
- supraceliac aorta clamped
- organs perfused with hyperosmotic, hyperkalemic solution contianing insulin, glucose, and reducing agents
- ventilator turned off unless extracting lungs
Order of organ removal
heart > lungs > liver > pancreas > small intestine > kidney
when does anesthesia time end in organ donation?
aortic cross-clamp
(unless lung procurement)
Multi-organ procurement generally takes about _____ hours
4 hours
Common physiologic derangements seen following brain death
- hypotension
- arterial hypoxemia
- hypothermia
- cardiac dysrhythmias
Respiratory management in brain dead patients
- TV 10-12 mL/kg
- PaCO2 30-35 mmHg
- pH 7.35-7.45
- PIP less than 40% to prevent oxygen toxicity
If harvesting heart-lung, FiO2 should be kept below _____
40%
hemodynamic goals of brain-dead patients
- CVP 10-12 cmH2O
- MAP 60-100 mmHg
- SBP > 100 mmHg
- PCWP > 12 mmHg
- SVR 800-1200
- UOP > 1 mL/kg/hr
Treatment for bradycardia if also hypotensive
isoproterenol
dopamine
epinephrine
pacing
(resistant to atropine)
donor patients should maintain HCT greater than _____
30
are muscle relaxants necessary in organ procurement?
yes
use a long-acting neuromuscular blocker
Treatment for hypertension in donor patients
volatile agents, nitroprusside, or nitroglycerin
Standard monitoring in donor patients
standard ASA, A-line, CVP, foley
monitor ABG, H&H, electrolytes, and glucose hourly
(for lung and heart, check ABG every 30 minutes)
What happens when a donor patient goes into cardiac arrest?
begin CPR and rapid procurement of liver and kidneys
(patient is not eligible for heart and lung procurement)
How to increase urine output
check adequate volume and BP
consider dopamine, lasix, and mannitol
what can be given if donor patient develops diabetes inspidus?
vasopressin or DDAVP
Peritoneal vs Hemodialysis
hemodialysis: blood is pumped out of your body to an artificial kidney machine, and returned to your body by tubes that connect you to the machine.
peritoneal dialysis: the inside lining of your own belly acts as a natural filter. Wastes are taken out by means of a cleansing fluid called dialysate, which is washed in and out of your belly in cycles
first sign of myocardial ischemia
wall motion abnormality in TEE
ASRA
american society of regional anesthesia
which narcotics should not be used in ESRD?
morphine and demerol
fentanyl infusion rate
0.25 - 1.0 mcg/kg/hr
remifentanyl infusion rate
0.05 - 2 mcg/kg/hr
Fenoldapam
Dopamine-1 agonist
(specific to the kidneys)
used in the prophylaxis and attenuation of contrast-induced nephropathy
Why is Ketoralac contraindicated in patients with compromised renal function?
COX inhibitor
causes inhibition of prostaglandin synthesis which leads to decreased GFR, renal blood flow, and increased renal vascular resistance
may result in hyperkalemia
ATN
acute tubular necrosis
acute tubular necrosis
intrinsic acute renal fialure
most common cause for renal failure in the perioperative period, accounting for up to 75% of cases
(2) major causes of ATN
ischemia and nephrotoxins
Nephrotoxic agnets
- antibiotics
- aminoglycosides, cephalosporins, penicillins, vancomycin, sulonamides, and amphotericin B
- IV contrast
- anesthetic agents
- NSAIDs
- myoglobin
- chemotherapeutic agents
prerenal oliguria
inadequate urinary output
< 400 cc/day
causes of prerenal oliguria
- hypovolemia
- mechanical ventilation
- cardiomyopathy
- aortic stenosis
- medications that impair renal autoregulaiton
- NSAIDsm ACE inhibitors, ARBs
laboratory tests indicative or prerenal oliguria
- specific gravity > 1.018
- osmolality > 500 mmol/kg
- urine/plasma urea nitrogen > 8
AKI
acute kidney injury
acute kidney injury
abrupt reduction in kidney function
(within 48 hours)
chronic kidney disease
decreased GFR persisting over 3 months
GFR < 15
Lisinopril
ACE inhibitor
Lasix
loop diuretic
Novolog
fast-acting insulin
hemodynamic goals in mitral stenosis
adequate preload
maintain contractility
reduce heart rate
increase SVR
decrease PVR
SIRS
systemic inflammatory response syndrome
Systemic Inflammatory Response Syndrome
includes 2 of the following:
fever > 38, or chills < 36
heart rate > 90
RR> 20 or PaCO2 < 32 mmHg
WBC > 12,000 per mm3 or 10% immature forms
septic shock
hypermetabolic state in which the body’s ability to extract, deliver, and utilize oxygen is impaired secondary to endotoxemia which can lead to metabolic acidosis and multiorgan dysfunction syndrome (MODS)
hemodynamic conditions in septic shock
BP < 90 mmHg
MAP < 60 mmHg
clinical signs of septic shock
elevated LFTs
altered mental status
ARDS
elevated renal markers
infusion rate of Vasopressin
0.01 - 0.04 units/min
signs of propofol infusion syndrome
cardiac failure
rhabdomyolysis
severe metabolic acidosis
renal failure
dosing leading to propfol infusion syndrome
greater than 5mg/kg/hour for over 2 days
Prerenal Azotemia
most common cause of acute renal failure
excess of nitrogen compounds in your blood stream due to a lack of blood flow to each kidney
normal GFR
90 - 120 mL/min/1.73 m2
nephrotic syndrome
kidney disorder that causes the body to excrete too much protein in the urine
name for infection from hospital
nosocomial infection
lowest age of pediatric in outpatient surgery
60 weeks gestational
following a cold, a patient should wait ______ weeks before elective surgery
2 - 4 weeks
aortic valve stenosis less than _____ is considered severe
1 cm2
each hospital is required to own ____ bottles of dantrolene if they have sux or agents
32 bottles
STOP BANG
snore
tired
observed apnea
pressure
BMI > 35
age > 50
neck circumference > 17in
gender: male