Primary Ovarian Insufficiency

Question 1

Definition

Answer 1

a distinct clinical entity with multiple etiologies, characterized by hypergonadotrophic hypogonadism in women aged younger than 40 years

Question 2

Early menopause

Answer 2

Menopause occurring between ages of 40-45. These women are also at increased risk for the LT effects of early estrogen deficiency. ACOG supports the use of HT for women with POI and early menopause until the average age of menopause

Question 3

Etiologies

Answer 3

(1) Genetic (2) Autosomal effects (3) Toxic, infectious and metabolic

Question 4

Genetic Disorders

Answer 4

(1) X Chromosome disorders (including Turner Syndrome); (2) Disorders of the X chromosome (including Fragile X syndrome); (3) mutations involving other enzymes and reproductive hormones

Question 5

Autosomal Effects

Answer 5

1. Autoimmune polyendocrine syndromes 2. Dry eye syndrome 3. Myasthenia gravis 4. Rhematioc arthtis 5. Systemic Lupus erythematosus 6. Congenetical thymic aplasia

Question 6

Toxic, infectious, and metabolic

Answer 6

(1) Infections - mumps, HIV (2) tabacco smoke and fossil fuel (3) metabolic - PCOS

Question 7

Iatrogenic

Answer 7

Surgical menopause or Chemotherapy/radiation induced menopause

Question 8

Diagnosis

Question 9

Management

Question 10

Ramifications