Primary Myelofibrosis Flashcards
1
Q
megs
A
look bizarre
2
Q
Early Primary Myelofibrosis vs ET
A
VERY hard to tell apart
Reticulin stain would show more reticulin fibers in PM than in ET (early marker of fibrosis)
3
Q
Jak2 mutation
A
In ~50% of cases
4
Q
Clinical Presentation
A
Thrombosis
Throbocytosis and/or leuko-erythroblast picture
5
Q
Morphology
A
Increased Megs
bizarre shapes
clustering
fibrosis
Very unique looking
6
Q
Immunophenotype
A
No known features
7
Q
Prognosis
A
Usually shorter survival than ET
Can progress to marrow failure, acute leukemia
