Essential Thrombocythemia Flashcards
1
Q
Jak2 mutations
A
in ~50% of cases…detectable in blood leukocytes
2
Q
Clinical Presentation
A
Thrombosis
Remember: increased platelets can also be due to iron deficiency, infection, chronic inflammation
3
Q
Morphology
A
Increased megs
(large and weird looking even for Megs!!)
Megs tend to cluster
4
Q
Immunophenotype
A
No known features
5
Q
Prognosis
A
> 10 yrs survival is common
can progress to myelofibrosis, MDS, acute leukemia
6
Q
Main difference b/w P.vera and ET
A
Megs in ET look bizarre
