Primary hyperaldosteronism/ Conn's syndrome Flashcards
1
Q
What?
A
Increased mineralocorticoid secretion from adrenal cortex
Excess aldosterone production -> sodium retention, potassium loss
2
Q
What does this result in?
A
Low renin levels
3
Q
Causes?
A
Hyperplasia
Tumours
4
Q
Who?
A
Females > males
30- 50’s
5
Q
How to distinguish primary ad secondary?
A
Secondary = excess renin
6
Q
Presentation?
A
Hypertension Hypokalaemia (<3,5mmol/L) (frequently not present) Muscle weakness Nocturia Tetany Can have no symptoms Headaches
7
Q
Investigations?
A
Elevated plasma aldosterone level
- Not suppressed with 2L or 0.9% saline over 4 hours
Suppressed plasma renin
8
Q
Which drugs should be discontinued?
A
Beta- blockers
ACEI
Angiotensin II receptor antagonists
9
Q
Management?
A
Surgical removal of adenoma
Hyperplasia - treat with spironolactone
